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A physiologically based model for denitrogenation kinetics

机译：基于生理的脱氮动力学模型

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摘要

Under normal conditions we continuously breathe 78% nitrogen (N2) such that the body tissues and fluids are saturated with dissolved N2. For normobaric medical gas administration at high concentrations, the N2 concentration must be less than that in the ambient atmosphere; therefore, nitrogen will begin to be released by the body tissues. There is a need to estimate the time needed for denitrogenation in the planning of surgical procedures. In this paper we will describe the application of a physiologically based pharmacokinetic model to denitrogenation kinetics. The results are compared to the data resulting from experiments in the literature that measured the end tidal N2 concentration while breathing 100% oxygen in the form of moderately rapid and slow compartment time constants. It is shown that the model is in general agreement with published experimental data. Correlations for denitrogenation as a function of subject weight are provided.
机译：在正常条件下，我们连续呼吸78％的氮（N 2 ），使人体组织和体液中充满溶解的N 2 。对于高浓度的常压医用气体管理，N 2 的浓度必须小于环境大气中的浓度。因此，氮将开始被人体组织释放。在手术程序的规划中，需要估计脱氮所需的时间。在本文中，我们将描述基于生理的药代动力学模型在脱氮动力学中的应用。将结果与文献中的实验数据进行比较，该实验测量潮气末N 2 的浓度，同时以中等快慢间隔时间常数的形式呼吸100％的氧气。结果表明，该模型与已发表的实验数据基本吻合。提供了脱氮与受试者体重的关系。

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