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首页> 外文期刊>Medicine. >Diurnal Variations in Blood Flow at Optic Nerve Head and Choroid in Healthy Eyes: Diurnal Variations in Blood Flow
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Diurnal Variations in Blood Flow at Optic Nerve Head and Choroid in Healthy Eyes: Diurnal Variations in Blood Flow

机译：健康人眼睛视神经头部和脉络膜的血流量日变化：血流量的日变化

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Abstract: To investigate the diurnal variations of the ocular blood flow in healthy eyes using laser speckle flowgraphy (LSFG), and to determine the relationship of the diurnal variations between the ocular blood flow and other ocular parameters. This prospective cross-sectional study was conducted at Nagoya University Hospital. We studied 13 healthy volunteers whose mean age was 33.5?±?7.6 years. The mean blur rate (MBR), expressing the relative blood flow, on the optic nerve head (ONH) and choroidal blood flow was determined by LSFG (LSFG-NAVI) every 3 hours from 6:00 to 24:00 hours. The intraocular pressure (IOP), choroidal thickness measured by enhanced depth imaging optical coherence tomography, systolic (SBP) and diastolic (DBP) blood pressure, and heart rate (HR) in the brachial artery were also recorded. We evaluated the diurnal variations of the parameters and compared the MBR to the other parameters using a linear mixed model. The diurnal variations of the MBR on the ONH varied significantly with a trough at 9:00 hours and a peak at 24:00 hours (P?P?=?0.001). The IOP (P?P?P?=?0.005), DBP (P?=?0.001), and HR (P?P?=?0.002), mean arterial pressure (P?=?0.023), and mean ocular perfusion pressure (P?=?0.047). We found significant diurnal variations in the ONH and choroidal blood flow. Although the ONH blood flow had its own diurnal variation because of strong autoregulation, the choroidal blood flow was more likely affected by systemic circulatory factors because of poor autoregulation.
机译：摘要：利用激光散斑流描记法（LSFG）研究健康眼中眼血流量的日变化，并确定眼血流量与其他眼参数之间的日变化关系。这项前瞻性横断面研究是在名古屋大学医院进行的。我们研究了13位平均年龄为33.5±7.6年的健康志愿者。视神经头（ONH）和脉络膜血流的平均模糊率（MBR）表示从6:00到24:00的每3小时的LSFG（LSFG-NAVI）。还记录了眼内压（IOP），通过增强深度成像光学相干断层扫描仪测量的脉络膜厚度，收缩压（SBP）和舒张压（DBP）血压以及肱动脉的心率（HR）。我们评估了参数的日变化，并使用线性混合模型将MBR与其他参数进行了比较。 ONH上MBR的昼夜变化显着变化，在9:00小时达到一个低谷，在24:00小时达到一个峰值（P？P？=？0.001）。 IOP（P？P？P？= 0.005），DBP（P？= 0.001）和HR（P？P？= 0.002），平均动脉压（P？= 0.023）和平均眼灌注压力（P≤0.047）。我们发现ONH和脉络膜血流的昼夜变化很大。尽管由于强烈的自律调节，ONH血流有其自身的昼夜变化，但由于自律调节差，脉络膜血流更可能受到全身循环因子的影响。

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