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Neurointegrity and neurophysiology: astrocyte, glutamate, and carbon monoxide interactions

机译：神经完整性和神经生理学：星形胶质细胞，谷氨酸和一氧化碳相互作用

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Astrocyte contributions to brain function and prevention of neuropathologies are as extensive as that of neurons. Astroglial regulation of glutamate, a primary neurotransmitter, is through uptake, release through vesicular and non-vesicular pathways, and catabolism to intermediates. Homeostasis by astrocytes is considered to be of primary importance in determining normal central nervous system health and central nervous system physiology - glutamate is central to dynamic physiologic changes and central nervous system stability. Gasotransmitters may affect diverse glutamate interactions positively or negatively. The effect of carbon monoxide, an intrinsic central nervous system gasotransmitter, in the complex astrocyte homeostasis of glutamate may offer insights to normal brain development, protection, and its use as a neuromodulator and neurotherapeutic. In this article, we will review the effects of carbon monoxide on astrocyte homeostasis of glutamate.
机译：星形胶质细胞对脑功能和神经病理学的预防作用与神经元一样广泛。谷氨酸（主要的神经递质）的星形胶质调节是通过摄取，通过水泡和非水泡途径释放以及对中间产物的分解代谢。在确定正常的中枢神经系统健康和中枢神经系统生理中，星形胶质细胞的稳态被认为是最重要的-谷氨酸对动态生理变化和中枢神经系统稳定性至关重要。气体递质可以正面或负面地影响各种谷氨酸的相互作用。一氧化碳（一种固有的中枢神经系统气体递质）对复杂的谷氨酸星形胶质细胞稳态的影响可能为正常大脑的发育，保护及其作为神经调节剂和神经治疗剂的用途提供见解。在本文中，我们将回顾一氧化碳对谷氨酸星形胶质细胞稳态的影响。

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