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首页> 外文期刊>European Journal of Translational Myology >Cellular Cardiomyoplasty using autologous satellite cells. From experimental to clinical study
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Cellular Cardiomyoplasty using autologous satellite cells. From experimental to clinical study

机译：使用自体卫星细胞的细胞心肌移植术。从实验到临床研究

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Adult mammalian ventricular myocytes lack regenerative capability, consequently an injured heart is normally repaired by scar formation, hypertrophy of surviving myocytes, and hyperplasia of non-muscle cells. The possible existence of stem cells or progenitor cells for myocardium has been suggested recently, however it is clear that functionally significant myocardial regeneration has not been documented in diseased or injured heart. Contribution of other cells to the formation of ventricular myocytes appears to be negligible as evidenced by the consistent formation of scar after myocardial infarction. Satellite cells are adult stem cells responsible for growth, repair, and maintain homeostasis of skeletal muscle. We have been using autologous satellite cells for myocardial regeneration in dogs since 1989 and have applied this procedure to patients in 2001. Satellite cells have been successfully isolated, labeled, and implanted into injured heart with neomyocardial formation and functional improvement. Viable muscle cells with clear labeling are found in the infarct area after cell implantation. The labeled muscle cells have intercalated disks at cellular junctions. Significant improvements in contractile function are only observed in the animals that have successful engraftment after cell transplantation. Marked improvement in ejection fraction, myocardial perfusion, and local contractility are also found for patients after cellular cardiomyoplasty using autologous satellite cells. Most importantly, a heart failure patient after cellular cardiomyoplasty without conjunctional surgical procedure has recovered from congestive heart failure with significant improvement in myocardial perfusion, contractility, and metabolic activity at sits of cell implantation. Transplantation of satellite cells into injured heart can be a new treatment for myocardial infarction and heart failure.locyte-
机译：成年哺乳动物的心室肌细胞缺乏再生能力，因此受伤的心脏通常可以通过疤痕形成，存活的心肌细胞肥大和非肌肉细胞增生来修复。最近已经提出了心肌干细胞或祖细胞的可能存在，但是很明显，在患病或受伤的心脏中尚未记录到功能上重要的心肌再生。心肌梗死后瘢痕的持续形成证明，其他细胞对心室肌细胞形成的贡献微不足道。卫星细胞是负责骨骼肌生长，修复和维持稳态的成体干细胞。自1989年以来，我们一直在使用自体卫星细胞在狗中进行心肌再生，并在2001年将这种方法应用于患者。已经成功地分离，标记了卫星细胞，并将其植入具有心肌新形成和功能改善的受损心脏中。植入细胞后，在梗死区域发现了标记清晰的活肌细胞。标记的肌肉细胞在细胞交界处有插入的椎间盘。仅在细胞移植后成功植入的动物中观察到收缩功能的显着改善。使用自体卫星细胞进行细胞心肌成形术后，患者的射血分数，心肌灌注和局部收缩力也得到了明显改善。最重要的是，在没有联合外科手术的情况下进行细胞心肌成形术后的心力衰竭患者已经从充血性心力衰竭中恢复过来，并显着改善了细胞植入部位的心肌灌注，收缩力和代谢活性。将卫星细胞移植到受伤的心脏中可能是治疗心肌梗塞和心力衰竭的新方法。

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