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首页> 外文期刊>Memorias do Instituto Oswaldo Cruz >T-cell receptor Vβ repertoire of CD8+ T-lymphocyte subpopulations in cutaneous leishmaniasis patients from the state of Rio de Janeiro, Brazil
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T-cell receptor Vβ repertoire of CD8+ T-lymphocyte subpopulations in cutaneous leishmaniasis patients from the state of Rio de Janeiro, Brazil

机译：来自巴西里约热内卢州皮肤利什曼病患者的CD8 + T淋巴细胞亚群的T细胞受体Vβ组成

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摘要

In human cutaneous leishmaniasis (CL), the immune response is mainly mediated by T-cells. The role of CD8+ T-lymphocytes, which are related to healing or deleterious functions, in affecting clinical outcome is controversial. The aim of this study was to evaluate T-cell receptor diversity in late-differentiated effector (LDE) and memory CD8+ T-cell subsets in order to create a profile of specific clones engaged in deleterious or protective CL immune responses. Healthy subjects, patients with active disease (PAD) and clinically cured patients were enrolled in the study. Total CD8+ T-lymphocytes showed a disturbance in the expression of the Vβ2, Vβ9, Vβ13.2, Vβ18 and Vβ23 families. The analyses of CD8+ T-lymphocyte subsets showed high frequencies of LDE CD8+ T-lymphocytes expressing Vβ12 and Vβ22 in PAD, as well as effector-memory CD8+ T-cells expressing Vβ22. We also observed low frequencies of effector and central-memory CD8+ T-cells expressing Vβ2 in PAD, which correlated with a greater lesion size. Particular Vβ expansions point to CD8+ T-cell clones that are selected during CL immune responses, suggesting that CD8+ T-lymphocytes expressing Vβ12 or Vβ22 are involved in a LDE response and that Vβ2 contractions in memory CD8+ T-cells are associated with larger lesions.
机译：在人类皮肤利什曼病（CL）中，免疫反应主要由T细胞介导。与愈合或有害功能有关的CD8 + T淋巴细胞在影响临床结果中的作用尚存争议。这项研究的目的是评估晚期分化效应子（LDE）和记忆CD8 + T细胞亚群中的T细胞受体多样性，以建立参与有害或保护性CL免疫应答的特定克隆的概况。健康受试者，患有活动性疾病（PAD）的患者和临床治愈的患者参加了研究。 CD8 + T淋巴细胞总数显示Vβ2，Vβ9，Vβ13.2，Vβ18和Vβ23家族的表达受到干扰。 CD8 + T淋巴细胞亚群的分析显示，PAD中表达Vβ12和Vβ22的LDE CD8 + T淋巴细胞以及表达Vβ22的效应记忆CD8 + T细胞的频率很高。我们还观察到PAD中表达Vβ2的效应子和中央记忆CD8 + T细胞的频率较低，这与更大的病变大小相关。特定的Vβ扩增指向在CL免疫反应期间选择的CD8 + T细胞克隆，表明表达Vβ12或Vβ22的CD8 + T淋巴细胞参与LDE反应，并且记忆CD8 + T细胞中的Vβ2收缩与更大的病变相关。

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