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首页> 外文期刊>Molecular and Cellular Pharmacology >Prostate Cancer: Detection using Multiparametric 1H-MRI
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Prostate Cancer: Detection using Multiparametric 1H-MRI

机译：前列腺癌：使用多参数1H-MRI检测

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Sh Faisal 14.00 Magnetic resonance imaging (MRI) offers the possibility to accurately detect, localize, and stage prostate cancer, thereby assisting in the selection of an individualized course of treatment. Conventional, anatomical MRI (T2-weighted MRI) lacks the required sensitivity and specificity, in identifying prostate cancer foci, especially in the transition zone, in areas of post-biopsy hemorrhage, and in the setting of post-treatment change. In addition, T2-weighted MRI is suboptimal in determining the presence of extracapsular extension (ECE), which can be the most important factor for selection of an individualized therapy and for predicting the risk of tumor recurrence. Advanced MRI techniques comprising of dynamic contrast enhanced -MRI (DCE-MRI) that provides vascular information, diffusion-weighted MRI (DWI) that provides biophysical information, and magnetic resonance spectroscopic imaging (MRSI) that provides metabolic information can assist in overcoming the limitations of conventional anatomical MRI. In this article, we provide a brief review of these advanced imaging techniques and how they correlate with pathologic findings in prostate cancer. Advanced MRI techniques may increase the specificity of conventional MRI by identifying functional, metabolic, and microstructural changes of the prostate that occur in areas of cancer. MRSI and DWI have added value in detecting tumor within the transitional zone of the prostate, while MRSI and DCE may assist in predicting the presence of ECE, as well as in evaluating for recurrent tumor following hormonal or radiation therapy. Using a combined multi-parametric approach can provide a thorough evaluation for the presence and extent of prostate cancer using MRI. Normal 0 false false false EN-US X-NONE X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:12.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin;}
机译：Sh Faisal 14.00磁共振成像（MRI）提供了准确检测，定位和分期前列腺癌的可能性，从而有助于选择个性化的治疗方案。传统的解剖MRI（T2加权MRI）在确定前列腺癌病灶（尤其是在过渡区，活检后出血区域以及治疗后变化的情况下）缺乏所需的敏感性和特异性。此外，T2加权MRI在确定囊外扩张（ECE）的存在时不是最佳选择，这可能是选择个性化疗法和预测肿瘤复发风险的最重要因素。先进的MRI技术包括提供血管信息的动态对比增强-MRI（DCE-MRI），提供生物物理信息的弥散加权MRI（DWI）和提供代谢信息的磁共振波谱成像（MRSI）可以帮助克服局限性常规解剖MRI。在本文中，我们简要介绍了这些先进的成像技术，以及它们与前列腺癌的病理结果之间的关系。先进的MRI技术可以通过识别在癌症区域发生的前列腺的功能，代谢和微结构变化来提高传统MRI的特异性。 MRSI和DWI在检测前列腺移行区内的肿瘤方面具有附加价值，而MRSI和DCE可能有助于预测ECE的存在，以及评估激素或放射治疗后的复发性肿瘤。使用组合的多参数方法可以使用MRI对前列腺癌的存在和程度进行全面评估。正常0否否否EN-US X-NONE X-NONE / *样式定义* / table.MsoNormalTable {mso-style-name：“ Table Normal”; mso-tstyle-rowband-size：0; mso-tstyle-colband-size：0; mso-style-noshow：是; mso-style-priority：99; mso-style-parent：“”; mso-padding-alt：0in 5.4pt 0in 5.4pt; mso-para-margin：0in; mso-para-margin-bottom：.0001pt; mso分页：寡妇孤儿;字体大小：12.0pt;字体家族：“ Calibri”，“ sans-serif”; mso-ascii-font-family：Calibri; mso-ascii-theme-font：minor-latin; mso-hansi-font-family：Calibri; mso-hansi-theme-font：minor-latin;}

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