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首页> 外文期刊>Molecular biology international >Protein Methylation and Stress Granules: Posttranslational Remodeler or Innocent Bystander?
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Protein Methylation and Stress Granules: Posttranslational Remodeler or Innocent Bystander?

机译：蛋白甲基化和应激颗粒：翻译后重塑还是无辜的旁观者？

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Stress granules contain a large number of post-translationally modified proteins, and studies have shown that these modifications serve as recruitment tags for specific proteins and even control the assembly and disassembly of the granules themselves. Work originating from our laboratory has focused on the role protein methylation plays in stress granule composition and function. We have demonstrated that both asymmetrically and symmetrically dimethylated proteins are core constituents of stress granules, and we have endeavored to understand when and how this occurs. Here we seek to integrate this data into a framework consisting of the currently known post-translational modifications affecting stress granules to produce a model of stress granule dynamics that, in turn, may serve as a benchmark for understanding and predicting how post-translational modifications regulate other granule types.
机译：应激颗粒含有大量的翻译后修饰蛋白，研究表明这些修饰可作为特定蛋白的募集标签，甚至可以控制颗粒本身的组装和拆卸。来自我们实验室的工作侧重于蛋白质甲基化在应激颗粒成分和功能中的作用。我们已经证明，不对称和对称的二甲基化蛋白质都是应激颗粒的核心成分，并且我们努力了解何时以及如何发生这种情况。在这里，我们试图将这些数据整合到一个框架中，该框架由影响应力颗粒的当前已知的翻译后修饰组成，以产生应力颗粒动力学模型，从而可以作为理解和预测翻译后修饰如何调控的基准其他颗粒类型。

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