Will we cure cancer by sequencing thousands of genomes?

Joshua M Nicholson

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Will we cure cancer by sequencing thousands of genomes?

机译：我们将通过对数千个基因组测序来治愈癌症吗？

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The promise to understand cancer and develop efficacious therapies by sequencing thousands of cancers has not occurred. Mutations in specific genes termed oncogenes and tumor suppressor genes are extremely heterogeneous amongst the same type of cancer as well as between cancers. They provide little selective advantage to the cancer and in functional tests have yet to be shown to be sufficient for transformation. Here I discuss the karyotyptic theory of cancer and ask if it is time for a new approach to understanding and ultimately treating cancer.

机译：通过对数千种癌症进行测序来了解癌症并开发有效疗法的承诺尚未实现。在相同类型的癌症之间以及癌症之间，称为癌基因和抑癌基因的特定基因的突变极为异质。它们几乎没有为癌症提供选择性优势，并且在功能测试中尚未证明足以进行转化。在这里，我讨论了癌症的核型理论，并询问是否是时候采用一种新的方法来理解和最终治疗癌症。

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《Molecular cytogenetics》 |2013年第19期|共页
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Joshua M Nicholson;
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中图分类分子遗传学;
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1. Will we cure cancer by sequencing thousands of genomes? [J] . Joshua M Nicholson Molecular Cytogenetics . 2013,第1期

机译：我们将通过测序数千个基因组来治愈癌症吗？
2. Debunking the myth that whole-genome sequencing infringes thousands of gene patents [J] . Holman Christopher M. Nature biotechnology . 2012,第3期

机译：揭穿全基因组测序侵犯数千项基因专利的神话
3. Genome-scale sequencingguides treatment in rarecancer type.Doctors use clues from genome sequencing of rare tonguetumor to personalize treatment regimen. [J] . Anonymous Future oncology . 2010,第10期

机译：基因组规模的测序指导了罕见癌类型的治疗。医生利用罕见舌癌基因组测序的线索来个性化治疗方案。
4. Genome-wide identification of TSS, promoters and transcriptional factor binding sites in E. coli K-12 bacterial genome: Development of a bioinformatics tool for the graphical display of the high throughput sequencing data [C] . Enrique Morett, Leticia Vega-Alvarado, Ryosuke L.A.Watanabe, The 7th Asia-Pacific Bioinformatics Conference（第七届亚太生物信息学大会） . 2009

机译：大肠杆菌K-12细菌基因组中TSS，启动子和转录因子结合位点的全基因组鉴定：开发用于以图形方式显示高通量测序数据的生物信息学工具
5. Bioinformatics: Using Computational Techniques (Whole Genome & Rna-Sequencing) to Understand Bacterial Genome Evolution and Biopharmaceutical Development =Bioinformatics: Using Computational Techniques (Whole Genome & RNA-Sequencing) to Understand Bac [D] . Duncan, David Jonith. 2020

机译：生物信息学：使用计算技术（全基因组和RNA测序）了解细菌基因组进化和生物制药发育=生物信息学：使用计算技术（全基因组＆amp; RNA测序）来理解BAC
6. Will we cure cancer by sequencing thousands of genomes? [O] . Joshua M Nicholson 2013

机译：我们将通过测序数千个基因组来治愈癌症吗？
7. Will we cure cancer by sequencing thousands of genomes? [O] . Joshua M Nicholson 2013

机译：我们将通过测序数千个基因组来治愈癌症吗？

Will we cure cancer by sequencing thousands of genomes?

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