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首页> 外文期刊>Modern Pathology >Expression and possible role of hPTTG1|[sol]|securin in cutaneous malignant melanoma
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Expression and possible role of hPTTG1|[sol]|securin in cutaneous malignant melanoma

机译：hPTTG1 | [sol] | securin在皮肤恶性黑色素瘤中的表达及其可能的作用

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Human pituitary tumour-transforming gene 1 or hPTTG1 is a proto-oncogene that codes for securin, a protein involved in sister chromatid separation. Based on previous microarray data, we studied the expression of hPTTG1/securin in melanocytic lesions. In contrast to nevi and radial growth phase melanomas, securin was expressed by scattered cells in the vertical growth phase, suggesting a role in tumour progression. In a series of 29 nodular and 29 superficial spreading melanomas, matched for all histological prognostic parameters, securin expression was significantly correlated with the nodular subtype (P=0.018) and not related to thickness. In other cancers, hPTTG1 is involved in various oncogenic pathways, including induction of neovascularisation and aneuploidy, and inhibition of p53 activity. We found coexpression of securin with wild-type p53 in the same neoplastic cells in a minority of melanomas. Expression of securin was significantly correlated with the extent of aneuploidy but not with basic fibroblast growth factor immunoreactivity or microvessel density. DNA cytometry revealed that nuclei-overexpressing securin frequently showed tetraploidy or aneuploidy. Our data show that hPTTG1 is frequently overexpressed in nodular melanoma, and suggest that hPTTG1 may act as an oncogene in the vertical growth phase, either by inhibiting anaphase, thereby causing aneuploidy and genomic instability, or by modulating the function of p53, thereby impairing apoptosis.
机译：人垂体肿瘤转化基因1或hPTTG1是一种原癌基因，它编码securin（参与姐妹染色单体分离的蛋白质）。基于以前的芯片数据，我们研究了hPTTG1 / securin在黑素细胞病变中的表达。与痣和放射状生长期的黑色素瘤不同，在垂直生长期，分散细胞表达了securin，提示其在肿瘤进展中的作用。在一系列符合所有组织学预后参数的29例结节性和29例浅表性扩散性黑色素瘤中，securin表达与结节性亚型显着相关（P = 0.018），与厚度无关。在其他癌症中，hPTTG1参与多种致癌途径，包括诱导新血管形成和非整倍性，以及抑制p53活性。我们在少数黑色素瘤的同一肿瘤细胞中发现了securin与野生型p53的共表达。 Securin的表达与非整倍性程度显着相关，但与碱性成纤维细胞生长因子的免疫反应性或微血管密度无关。 DNA细胞计数显示，过表达核仁的securin经常显示四倍体或非整倍体。我们的数据表明，hPTTG1在结节性黑素瘤中经常过表达，提示hPTTG1可能在垂直生长期作为癌基因，可能是通过抑制后期，从而导致非整倍性和基因组不稳定，或者通过调节p53的功能，从而削弱细胞凋亡。 。

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