...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Molecular cytogenetics >Monitoring of gas station attendants exposure to benzene, toluene, xylene (BTX) using three-color chromosome painting
【24h】

Monitoring of gas station attendants exposure to benzene, toluene, xylene (BTX) using three-color chromosome painting

机译：使用三色染色体涂画监控加油站服务员的苯，甲苯，二甲苯（BTX）暴露

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background Chronic exposure of BTX (benzene, toluene, xylene) may lead to progressive degeneration of bone marrow, aplastic anemia and/or leukemia. In Brazil there is no self-service fuel in gas stations and attendants fill the fuel themselves. Due to this they are chronically exposed to high concentration of BTX. Occupational exposure to benzene has been associated with increased chromosomal aberrations in peripheral blood lymphocytes. Fluorescence in situ hybridization (FISH) using whole chromosome painting (wcp) probes allows the rapid detection of chromosomal aberration. In the present study three-color wcp probes for chromosomes 1, 2 and 4 were used for monitoring 60 gas station attendants. Results Blood tests were done and interviews were conducted for each worker. For searching for possible associations between the clinical characteristics and the frequency of chromosomal aberrations the workers were divided into two groups (≤ 10 chromosomal abnormalities per 1,000 metaphases and?>?10 chromosomal abnormalities per 1,000 metaphases).The studied workers had a low median age (36 year), albeit long period of BTX exposure (median was 16 years). Low prevalence of smoking and moderate consumption of alcoholic beverages were found in this population. The cytogenetic analysis showed 16.6% (10/60) of workers with a high frequency of chromosomal abnormalities (>10 chromosomal abnormalities per 1,000 metaphases). Translocations were the most frequently observed chromosome aberration. The statistical analysis revealed highly significant differences in skin color (p?=?0.002) and a weak significant differences in gender (p?=?0.052) distribution between the two groups. Conclusion 16.6% of the studied population showed elevated frequencies of chromosomal abnormalities, which is highly likely to be correlated with their exposure to BTX during their work. Therefore, further studies are needed for better characterize the work associated damage of the genome in gas station workers. It is necessary to better understand the risks that these workers are exposed, so that we can be effective in preventing diseases and maintaining the health of these workers and possibly the offspring.
机译：背景长期接触BTX（苯，甲苯，二甲苯）可能导致骨髓进行性变性，再生障碍性贫血和/或白血病。在巴西，加油站没有自助燃油，服务员自己也要加油。因此，它们长期暴露于高浓度的BTX中。职业性接触苯与外周血淋巴细胞染色体畸变增加有关。使用全染色体绘画（wcp）探针的荧光原位杂交（FISH）可以快速检测染色体畸变。在本研究中，用于1号，2号和4号染色体的三色wcp探针用于监测60个加油站服务员。结果对每个工人进行了血液检查并进行了访谈。为了寻找临床特征和染色体畸变频率之间的可能联系，将工人分为两组（每1000个中期≤10个染色体异常，每1000个中期≤10个染色体异常）。 （36岁），尽管长时间接触BTX（中位数为16年）。在该人群中发现吸烟率较低，并且适度饮酒。细胞遗传学分析显示16.6％（10/60）的工人发生染色体异常的频率很高（每1,000个中期> 10个染色体异常）。易位是最常观察到的染色体畸变。统计分析表明，两组之间的肤色高度差异显着（p≥0.002），而性别分布的显着差异较小（p≥0.052）。结论16.6％的研究人群的染色体异常发生频率升高，这很可能与他们在工作期间接触BTX有关。因此，需要进一步的研究来更好地表征加油站工人与基因组相关的工作损伤。有必要更好地了解这些工人面临的风险，以便我们能够有效地预防疾病，维护这些工人以及后代的健康。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号