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首页> 外文期刊>Modern Pathology >Loss of Expression of |[agr]|4|[bgr]|7 Integrin and L-selectin Is Associated with High-Grade Progression of Low-Grade MALT Lymphoma
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Loss of Expression of |[agr]|4|[bgr]|7 Integrin and L-selectin Is Associated with High-Grade Progression of Low-Grade MALT Lymphoma

机译：| [agr] | 4 | [bgr] | 7整联蛋白和L-选择蛋白的表达缺失与低度MALT淋巴瘤的高度进展有关

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Expression of adhesion molecule in low-grade B-cell mucosa-associated lymphoid tissue (MALT) lymphoma of the gastrointestinal tract has been reported in recent years, but these reports have primarily focused on low-grade gastrointestinal MALT lymphoma. In this study, we examined the lymphocytic homing receptor 47 integrin, L-selectin, and VLA-4 and mucosal addressin cell adhesion molecule-1 (MAdCAM-1) in low-grade lymphoma of the gastrointestinal tract and other organs such as the ocular adnexa and thyroid. We also observed changes in the expression pattern associated with high-grade transformation. Neoplastic cells in the gastrointestinal low-grade lymphoma and the low-grade component of high-grade MALT lymphoma were found to be 47 integrin+, L-selectin+, whereas the gastrointestinal high-grade component and diffuse large B-cell lymphoma were found to be 47 integrin-, L-selectin-. High endothelial venules in the gastric MALT lymphomas expressed MAdCAM-1. In the ocular adnexa low-grade MALT lymphoma, most cases were 47 integrin-, L-selectin+; and in the thyroid, most cases of both low- and high-grade MALT lymphoma were 47 integrin-, L-selectin-. These findings show that 47 integrin and L-selectin may play an important role in the lymphocyte homing of gastrointestinal low-grade MALT lymphoma and in the loss of 47 integrin expression throughout the course of high-grade progression.
机译：近年来已经报道了在胃肠道的低级B细胞粘膜相关淋巴样组织（MALT）淋巴瘤中粘附分子的表达，但是这些报道主要集中在低级胃肠道MALT淋巴瘤上。在这项研究中，我们检查了胃肠道和其他器官（例如眼）的低度淋巴瘤中的淋巴细胞归巢受体47整合素，L-选择素和VLA-4和黏膜寻址细胞粘附分子1（MAdCAM-1）附件和甲状腺。我们还观察到了与高级转化相关的表达模式的变化。胃肠低级淋巴瘤和高级别MALT淋巴瘤的低级成分中的肿瘤细胞为47整合素+，L-选择素+，而胃肠高级别成分和弥漫性大B细胞淋巴瘤为47个整联蛋白-，L-选择蛋白-。胃MALT淋巴瘤中的高内皮小静脉表达MAdCAM-1。在眼附件低度MALT淋巴瘤中，大多数病例为47整合素，L-选择素+。在甲状腺中，大多数低度和高度MALT淋巴瘤病例均为47整合素，L选择素。这些发现表明47种整联蛋白和L-选择蛋白可能在胃肠道低度MALT淋巴瘤的淋巴细胞归巢和整个高级进展过程中47种整联蛋白表达的丧失中起重要作用。

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