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首页> 外文期刊>Morbidity and Mortality Weekly Report: CDC Surveillance Summaries >Notes from the Field: Targeted Biomonitoring for GenX and Other Per- and Polyfluoroalkyl Substances Following Detection of Drinking Water Contamination a?? North Carolina, 2018
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Notes from the Field: Targeted Biomonitoring for GenX and Other Per- and Polyfluoroalkyl Substances Following Detection of Drinking Water Contamination a?? North Carolina, 2018

机译：现场注意事项：在检测到饮用水污染后，针对GenX和其他全氟和多氟烷基物质进行有针对性的生物监测北卡罗莱纳州，2018

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In June 2017, local health departments asked the North Carolina Department of Health and Human Services (NCDHHS) to provide health information and guidance regarding 2,3,3,3,-tetrafluoro-2-(1,1,2,2,3,3,3-heptafluoropropoxy)-propanoate (GenX) and other per- and polyfluoroalkyl substances (PFAS) that had been detected in the Cape Fear River, an important drinking water source (1). PFAS are a group of man-made chemicals that have been used in industry and consumer products worldwide since the 1950s. Most PFAS do not break down in the environment and can accumulate over time, resulting in increased human exposures. Limited studies in humans have indicated that some PFAS might affect reproduction, development, and the immune system and increase the risk for certain types of cancer (2). The source of GenX and other PFAS contamination in the Cape Fear River was a PFAS chemical manufacturing facility. After further investigation, the North Carolina Department of Environmental Quality identified GenX and other PFAS in surface water, air, and private wells close to the facility. As of April 2018, 837 private wells within a 5-mile radius of the facility had been tested; 207 (25%) had GenX levels exceeding the NCDHHS provisional drinking water health goal of 140 parts per trillion (ppt),* with a maximum measured GenX concentration of 4,000 ppt. The manufacturer began providing bottled water to residents living in homes with a well that exceeded the NCDHHS provisional drinking water health goal. In August 2018, NCDHHS worked with local health departments and asked CDC to quantify GenX and other PFAS in serum and urine specimens from a convenience sample of residents near the facility.
机译：2017年6月，当地卫生部门要求北卡罗来纳州卫生和公共服务部（NCDHHS）提供有关2,3,3,3，-tetrafluoro-2-（1,1,2,2,3的健康信息和指南）在重要的饮用水源Cape Fear River中检测到的1,3,3-七氟丙氧基）-丙酸酯（GenX）和其他全氟和多氟烷基物质（PFAS）（1）。 PFAS是一组人造化学物质，自1950年代以来已在全球工业和消费产品中使用。大多数PFAS不会在环境中分解，并且会随着时间的推移而积累，从而导致人体暴露增加。有限的人类研究表明，某些PFAS可能会影响生殖，发育和免疫系统，并增加某些类型癌症的风险（2）。 Cape Fear河中的GenX和其他PFAS污染源是PFAS化学生产设施。经过进一步调查后，北卡罗莱纳州环境质量局在工厂附近的地表水，空气和私人井中发现了GenX和其他PFAS。截至2018年4月，已在设施半径5英里范围内对837口私人井进行了测试; 207名（25％）的GenX水平超过了NCDHHS临时饮用水卫生目标140万亿分之一（ppt）*，GenX的最大测得浓度为4,000 ppt。制造商开始向居住在其水井中的水超出NCDHHS临时饮用水卫生目标的居民提供瓶装水。 2018年8月，NCDHHS与当地卫生部门合作，要求CDC对设施附近居民的便利样本中血清和尿液样本中的GenX和其他PFAS进行定量。

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