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首页> 外文期刊>Modern Pathology >Early Phase of Intestinal Mantle Cell Lymphoma: A Report of Two Cases Associated with Advanced Colonic Adenocarcinoma
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Early Phase of Intestinal Mantle Cell Lymphoma: A Report of Two Cases Associated with Advanced Colonic Adenocarcinoma

机译：肠套细胞淋巴瘤的早期阶段：2例与晚期结肠腺癌相关的报告。

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摘要

Intestinal mantle cell lymphoma characteristically produces multiple polyps, a finding reported as multiple lymphomatous polyposis. The early stages of intestinal mantle cell lymphoma before polyp formation and the pattern of initial lymph node invasion, however, have not been described. We recently encountered two cases of intestinal mantle cell lymphoma in their early development found incidentally associated with advanced colonic adenocarcinoma. We present herein the clinical, histopathological, immunohistochemical, and molecular genetic features of these two cases. In one case, a single polypoid mass was found with invasion limited to mucosa and submucosa of the terminal ileum and without lymph node compromise. In the second case, there were multiple mucosal aggregates of neoplastic cells without formation of polyps. Regional lymph nodes in the latter case showed either partial or complete involvement by lymphoma. In both cases, immunohistochemistry (CD20+, CD5+, cyclin D1+, CD10-, and CD23-), and demonstration of clonal immunoglobulin heavy chain and bcl-1 gene rearrangements by PCR analysis confirmed the diagnosis of mantle cell lymphoma.
机译：肠幔细胞淋巴瘤通常会产生多发性息肉，这一发现被报道为多发性淋巴瘤性息肉病。息肉形成前肠套细胞淋巴瘤的早期阶段和初始淋巴结浸润的模式尚未被描述。最近，我们发现了两例肠幔细胞淋巴瘤，它们的早期发展偶然发现与晚期结肠腺癌有关。我们在这里介绍这两种情况的临床，组织病理学，免疫组化和分子遗传学特征。在一种情况下，发现单个息肉样肿块，其侵袭仅限于回肠末端的粘膜和粘膜下层，而没有淋巴结受损。在第二种情况下，肿瘤细胞有多个粘膜聚集而不形成息肉。在后一种情况下，区域淋巴结显示淋巴瘤部分或完全累及。在这两种情况下，免疫组织化学（CD20 +，CD5 +，细胞周期蛋白D1 +，CD10-和CD23-），以及通过PCR分析证明克隆的免疫球蛋白重链和bcl-1基因重排均证实了套细胞淋巴瘤的诊断。

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