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首页> 外文期刊>Molecular vision >Study of 27 aqueous humor cytokines in patients with type 2 diabetes with or without retinopathy
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Study of 27 aqueous humor cytokines in patients with type 2 diabetes with or without retinopathy

机译：2型糖尿病伴或不伴视网膜病变的27种房水细胞因子的研究

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Purpose: To compare the changes in the levels of 27 aqueous humor cytokines between nondiabetic controls and patients with type 2 diabetes and to ascertain the association of these cytokines with diabetic retinopathy (DR). Methods: Undiluted aqueous humor samples were obtained from 102 nondiabetic patients (102 eyes) and 136 consecutive diabetic patients (136 eyes) who were divided into nine groups according to the Early Treatment of Diabetic Retinopathy Study severity scale. The concentrations of 27 cytokines in the aqueous humor samples were measured using a multiplex bead immunoassay. Results: Compared with the nondiabetic controls, the diabetic patients had significantly higher concentrations of interleukin-1β (IL-1β; p0.001), IL-6 (p0.001), IL-8 (p0.001), monocyte chemoattractant protein-1 (p0.001), interferon gamma-induced protein-10 (p0.001), and vascular endothelial growth factor (p0.001) in the aqueous humor. However, the IL-10 (p=0.002) and IL-12 (p=0.013) concentrations were significantly lower for the diabetic patients. There were no significant differences in the concentrations of other cytokines between the diabetic patients and the controls. The IL-1β, IL-6, IL-8, monocyte chemoattractant protein-1, and interferon gamma-induced protein-10 levels in the aqueous humor increased as the severity of DR increased. The correlation was significant. However, the vascular endothelial growth factor concentration was not correlated with the severity of DR. In addition, the IL-10 and IL-12 levels in the aqueous humor decreased as the severity of DR increased, and this negative correlation was significant. Conclusions: Various cytokines associated with inflammation and angiogenesis may contribute to the pathogenesis of DR, and chemokines may be more closely related to the development of this disease.
机译：目的：比较非糖尿病对照和2型糖尿病患者之间27种房水细胞因子水平的变化，并确定这些细胞因子与糖尿病性视网膜病（DR）的关联。方法：根据糖尿病视网膜病变的早期治疗研究严重程度评分表，从102例非糖尿病患者（102眼）和136例连续糖尿病患者（136眼）获得了未稀释的房水样本，这些患者分为9组。使用多重磁珠免疫测定法测量房水样品中27种细胞因子的浓度。结果：与非糖尿病对照组相比，糖尿病患者的白细胞介素-1β（IL-1β; p <0.001），IL-6（p <0.001），IL-8（p <0.001），单核细胞趋化蛋白的浓度明显升高。房水中的-1（p <0.001），γ干扰素诱导的蛋白10（p <0.001）和血管内皮生长因子（p <0.001）。但是，糖尿病患者的IL-10（p = 0.002）和IL-12（p = 0.013）浓度显着降低。糖尿病患者和对照组之间其他细胞因子的浓度没有显着差异。随着DR的严重性增加，房水中的IL-1β，IL-6，IL-8，单核细胞趋化蛋白-1和干扰素γ诱导的蛋白10水平增加。相关性是显着的。然而，血管内皮生长因子的浓度与DR的严重程度无关。另外，随着DR的严重性增加，房水中的IL-10和IL-12水平降低，并且这种负相关性是显着的。结论：与炎症和血管生成有关的多种细胞因子可能与DR的发病机制有关，而趋化因子可能与DR的发生密切相关。

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