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The clinical value of the quantitative detection of four cancer-testis antigen genes in multiple myeloma

机译：定量检测多发性骨髓瘤中四种癌-睾丸抗原基因的临床价值

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Background Cancer-testis (CT) antigen genes might promote the progression of multiple myeloma (MM). CT antigens may act as diagnostic and prognostic markers in MM, but their expression levels and clinical implications in this disease are not fully understood. This study measured the expression levels of four CT antigen genes in Chinese patients with MM and explored their clinical implications. Methods Real-time quantitative polymerase chain reaction (qPCR) was used to quantify the expression of MAGE-C1/CT7, MAGE-A3, MAGE-C2/CT10 and SSX-2 mRNA in 256 bone marrow samples from 144 MM patients. Results In the newly diagnosed patients, the positive expression rates were 88.5% for MAGE-C1/CT7, 82.1% for MAGE-C2/CT10, 76.9% for MAGE-A3 and 25.6% for SSX-2. The expression levels and the number of co-expressed CT antigens correlated significantly with several clinical indicators, including the percentage of plasma cells infiltrating the bone marrow, abnormal chromosome karyotypes and the clinical course. Conclusion MAGE-C1/CT7, MAGE-A3, MAGE-C2/CT10 and SSX-2 expression levels provide potentially effective clinical indicators for the auxiliary diagnosis and monitoring of treatment efficacy in MM.
机译：背景癌症睾丸（CT）抗原基因可能促进多发性骨髓瘤（MM）的进展。 CT抗原可以作为MM的诊断和预后标志物，但是它们在该疾病中的表达水平和临床意义尚不完全清楚。这项研究测量了中国MM患者四个CT抗原基因的表达水平，并探讨了其临床意义。方法采用实时定量聚合酶链反应（qPCR）定量分析144例MM患者256份骨髓样本中MAGE-C1 / CT7，MAGE-A3，MAGE-C2 / CT10和SSX-2 mRNA的表达。结果在新诊断的患者中，MAGE-C1 / CT7的阳性表达率为88.5％，MAGE-C2 / CT10的阳性表达率为82.1％，MAGE-A3的阳性表达率为76.9％，SSX-2的阳性表达率为25.6％。共表达的CT抗原的表达水平和数量与几种临床指标显着相关，包括浆细胞浸润骨髓的百分比，异常染色体核型和临床病程。结论MAGE-C1 / CT7，MAGE-A3，MAGE-C2 / CT10和SSX-2表达水平为辅助诊断和监测MM的治疗效果提供了潜在的有效临床指标。

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