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首页> 外文期刊>Molecular brain >Voltage-independent sodium channels emerge for an expression of activity-induced spontaneous spikes in GABAergic neurons
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Voltage-independent sodium channels emerge for an expression of activity-induced spontaneous spikes in GABAergic neurons

机译：电压无关的钠通道出现，用于在GABA能神经元中表达活性诱导的自发性尖峰

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Background Cerebral overexcitation needs inhibitory neurons be functionally upregulated to rebalance excitation vs. inhibition. For example, the intensive activities of GABAergic neurons induce spontaneous spikes, i.e., activity-induced spontaneous spikes (AISS). The mechanisms underlying AISS onset remain unclear. We investigated the roles of sodium channels in AISS induction and expression at hippocampal GABAergic neurons by electrophysiological approach. Results AISS expression includes additional spike capability above evoked spikes, and the full spikes in AISS comprise early phase (spikelets) and late phase, implying the emergence of new spikelet component. Compared with the late phase, the early phase is characterized as voltage-independent onset, less voltage-dependent upstroke and sensitivity to TTX. AISS expression and induction are independent of membrane potential changes. Therefore, AISS’s spikelets express based on voltage-independent sodium channels. In terms of AISS induction, the facilitation of voltage-gated sodium channel (VGSC) activation accelerates AISS onset, or vice versa. Conclusion AISS expression in GABAergic neurons is triggered by the spikelets based on the functional emergence of voltage-independent sodium channels, which is driven by intensive VGSCs’ activities.
机译：背景脑过度兴奋需要抑制性神经元功能上调，以重新平衡兴奋与抑制。例如，GABA能神经元的强烈活动诱导自发尖峰，即活动诱导的自发尖峰（AISS）。 AISS发作的潜在机制仍不清楚。我们通过电生理学方法研究了钠通道在AISS诱导和海马GABA能神经元表达中的作用。结果AISS表达包括在诱发的尖峰之上的额外尖峰能力，并且AISS中的完整尖峰包括早期（小穗）和晚期，暗示出现了新的小穗成分。与后期相比，早期的特点是与电压无关的起搏，较少的电压依赖性上冲程和对TTX的敏感性。 AISS的表达和诱导与膜电位变化无关。因此，AISS的小穗基于不依赖电压的钠通道表达。在AISS诱导方面，电压门控钠通道（VGSC）激活的促进会加速AISS的发作，反之亦然。结论GABA能神经元中AISS的表达是由小尖峰触发的，该小尖峰是由电压依赖性钠通道的功能性出现引起的，这是由强烈的VGSC的活动驱动的。

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