...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Molecular Plant-Microbe Interactions >A Rhamnose-Rich O-Antigen Mediates Adhesion, Virulence, and Host Colonization for the Xylem-Limited Phytopathogen Xylella fastidiosa
【24h】

A Rhamnose-Rich O-Antigen Mediates Adhesion, Virulence, and Host Colonization for the Xylem-Limited Phytopathogen Xylella fastidiosa

机译：鼠李糖丰富的O抗原介导木质部有限的植物病原体小叶小球藻的粘附，毒力和宿主定植。

获取原文
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Xylella fastidiosa is a gram-negative, xylem-limited bacterium that causes a lethal disease of grapevine called Pierce's disease. Lipopolysaccharide (LPS) composes approximately 75% of the outer membrane of gram-negative bacteria and, because it is largely displayed on the cell surface, it mediates interactions between the bacterial cell and its surrounding environment. LPS is composed of a conserved lipid A-core oligosaccharide component and a variable O-antigen portion. By targeting a key O-antigen biosynthetic gene, we demonstrate the contribution of the rhamnose-rich O-antigen to surface attachment, cell–cell aggregation, and biofilm maturation: critical steps for successful infection of the host xylem tissue. Moreover, we have demonstrated that a fully formed O-antigen moiety is an important virulence factor for Pierce's disease development in grape and that depletion of the O-antigen compromises its ability to colonize the host. It has long been speculated that cell-surface polysaccharides play a role in X. fastidiosa virulence and this study confirms that LPS is a major virulence factor for this important agricultural pathogen.
机译：木质小球藻是一种革兰氏阴性，木质部有限的细菌，可导致致命的葡萄疾病皮尔斯氏病。脂多糖（LPS）约占革兰氏阴性细菌外膜的75％，并且由于它主要显示在细胞表面，因此它介导细菌细胞与其周围环境之间的相互作用。 LPS由保守的脂质A核心寡糖成分和可变的O抗原部分组成。通过靶向关键的O抗原生物合成基因，我们证明了富含鼠李糖的O抗原对表面附着，细胞间聚集和生物膜成熟的贡献：成功感染宿主木质部组织的关键步骤。此外，我们已经证明，完整形成的O抗原部分是葡萄中Pierce病发展的重要毒力因子，O抗原的消耗会损害其在宿主中定植的能力。长期以来一直推测，细胞表面多糖在X.fastidiosa毒力中起作用，这项研究证实LPS是这种重要农业病原体的主要毒力因子。

著录项

相似文献

  • 外文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号