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首页> 外文期刊>Korean Circulation Journal >Association of Neutrophil Adhesion Molecules Expression and Change of sICAM-1 Concentration after Coronary Artery Stenting with Later Restenosis
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Association of Neutrophil Adhesion Molecules Expression and Change of sICAM-1 Concentration after Coronary Artery Stenting with Later Restenosis

机译：冠状动脉支架置入术后再狭窄后中性粒细胞粘附分子表达与sICAM-1浓度变化的关联

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Background Neointimal hyperplasia, as the most important mechanism of restenosis after intracoronary artery stenting, its severity is closely correlated with the degree of local inflammatory reaction initiated by vasular injury during stenting procedure. So, we proceeded this study to determine whether inflammatory markers such as CD11b/CD18 (Mac-1) adehsion molecules of neutrophils, sICAM-1 (soluble intercellular adhesion molecule-1), ESR, and CRP increase or not in the peripheral circulation after coronary artery stenting, and whether there is any association between these findings and the degree of later restenosis. Method 32 patients (chronic stable angina 4, unstable angina 17, acute myocardial infarction 11) underwent single vessel coronary artery stenting were enrolled in our study. Blood samples were obtained from peripheral vein just before coronary artery stenting and 48 hours thereafter. The degrees of CD11b/CD18 expression on the surface of neutrophils were analyzed by flow cytometry with monoclonal antibodies, and sICAM-1 by ELISA method. At each times, ESR and CRP were also measured. Follow-up coronary artery angiography was performed with QCA analysis at least 6 months later. We compared the each 48 hours values with the baseline (just before procedure) values. Percentage increments (as a ratio 48 hours values to baseline) of CD11b/CD18 expression, sICAM-1, ESR, and CRP levels were also compared with the results of follow-up QCA analysis. Results Restenosis (diameter stenosis ≥ 50%) occurred in 6 patients (19%) at follow up angiography. 48 hours values of CD11b/CD18 expression, sICAM-1, ESR, and CRP were significantly elevated from the baseline values (each p values, CD11b : Conclusions Through this study, we found that the activation of neutrophils was occurred, and that sICAM-1 level was increased after coronary artery stenting in the peripheral blood. There was some correlations between the degree of CD11b expression on the surface of neutrophils and the severity of late lumen loss of inserted stents. The measurements of increased neutrophil adhesion molecules of CD11b/CD18 levels at 48hrs after coronary stenting may have a value as the predictor of subsequent late restenosis.
机译：背景内膜增生是冠状动脉内支架置入术后再狭窄的最重要机制，其严重程度与支架置入过程中血管损伤引发的局部炎症反应程度密切相关。因此，我们进行了这项研究，以确定中性粒细胞的CD11b / CD18（Mac-1）黏附分子，sICAM-1（可溶性细胞间黏附分子-1），ESR和CRP等炎症标志物在外周血循环后是否增加冠状动脉支架置入，以及这些发现与后来的再狭窄程度之间是否存在任何关联。方法本研究纳入32例行单支冠状动脉支架置入术的患者（慢性稳定型心绞痛4例，不稳定型心绞痛17例，急性心肌梗塞11例）。在冠状动脉支架置入之前和之后48小时从外周静脉采集血样。用单克隆抗体通过流式细胞术分析中性粒细胞表面的CD11b / CD18表达程度，通过ELISA法分析sICAM-1。每次都测量ESR和CRP。至少6个月后进行QCA分析并进行随访冠状动脉造影。我们将每个48小时的值与基线（在手术前）的值进行了比较。还将CD11b / CD18表达，sICAM-1，ESR和CRP水平的百分比增量（相对于基线的48小时值）与后续QCA分析的结果进行了比较。结果6例（19％）患者在随访血管造影时发生了再狭窄（直径狭窄≥50％）。 CD11b / CD18表达，sICAM-1，ESR和CRP的48小时值从基线值显着升高（每个p值CD11b：结论）通过这项研究，我们发现嗜中性粒细胞发生了活化，并且sICAM-在外周血中冠状动脉支架置入后，血浆中CD11b的表达水平增加了1，中性粒细胞表面CD11b的表达程度与晚期支架丢失的严重程度之间存在一定的相关性。冠状动脉支架置入后48小时的血脂水平可能具有随后再狭窄的预测指标。

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