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首页> 外文期刊>Khyber Medical University Journal >SENSITIVITY PATTERN OF BACTERIAL ISOLATES IN NEONATAL SEPSIS: A HOSPITAL BASED STUDY
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SENSITIVITY PATTERN OF BACTERIAL ISOLATES IN NEONATAL SEPSIS: A HOSPITAL BASED STUDY

机译：新生儿脓毒症细菌分离株的敏感性模式：基于医院的研究

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Objective: To determine the sensitivity pattern of bacterial isolates in neonatal sepsis at a tertiary care hospital of Peshawar. Methodology: This cross sectional study was carried out at the department of paediatrics, Rehman medical institute Peshawar, from 1st January 2006 to 30th June 2012. Out of 4900 neonates admitted to the department of neonatology during the study period, 2256 (46.04%) neonates had clinical signs and symptoms of sepsis. Only 440/2256 (19.5%) neonates with positive blood cultures were selected for the study. All the blood cultures were done following a standard protocol. Results: Out of 440 cases of neonatal sepsis, 309 (70.2%) were males and 131 (29.8%) were females. Mean age of patients was 8.93 ± 8.70 days. Nineteen different micro-organism were isolated in which Staphylococcus Aureus (n=282; 64.1%), Enterococcus fecalis (n=61; 13.9%), Klebsiella pneumonia (n=30; 6.8%) and Escherichia coli (n=25; 5.7%) were most common organism. Gram positive organisms were mostly sensitive to vancomycin, imepenime, ceoftaxime, amikacin and amoxacillin, while gram negative organisms were mostly sensitive to amikacin and imepenime. Overall penicillin and cephalosporin has shown high resistance to gram negative organism, while ampicillin was found to be resistant to both gram positive and gram negative organism. Conclusion: Staphylococcus Aureus, Enterococcus Fecalis, Klebsiella pneumonia and Escherichia coli are the commonest pathogens in neonatal sepsis in our set up. In era of highly resistant micro-organism, vancomycin, amikacin, cefotaxime, and imepinime may be considered as drug of choice for empirical treatment of neonatal sepsis on the basis of highest sensitivity amongst tested drugs.?
机译：目的：确定白沙瓦一家三级医院的新生儿败血症中细菌分离株的敏感性模式。方法：这项横断面研究是从2006年1月1日至2012年6月30日在雷曼医学研究所白沙瓦儿科进行的。在4900名新生儿中研究期间到新生儿科的2256名（46.04％）新生儿有败血症的临床体征和症状。本研究仅选择440/2256（19.5％）血液培养阳性的新生儿。所有血液培养均按照标准方案进行。结果：在440例新生儿败血症患者中，男性309例（70.2％），女性131例（29.8％）。患者的平均年龄为8.93±8.70天。分离出19种不同的微生物，其中金黄色葡萄球菌（n = 282; 64.1％），费氏肠球菌（n = 61; 13.9％），肺炎克雷伯菌（n = 30; 6.8％）和大肠埃希菌（n = 25; 5.7） ％）是最常见的生物。革兰氏阳性菌对万古霉素，丁烯肟，头孢噻肟，丁胺卡那霉素和阿莫西林最敏感，而革兰氏阴性菌对丁胺卡那霉素和二甲酰亚胺最敏感。总体而言，青霉素和头孢菌素对革兰氏阴性菌显示出高抗性，而氨苄青霉素被发现对革兰氏阳性和革兰氏阴性菌均具有抗性。结论：金黄色葡萄球菌，费卡利斯肠球菌，肺炎克雷伯菌和大肠杆菌是我们新生儿败血症中最常见的病原体。在高度耐药的微生物时代，万古霉素，丁胺卡那霉素，头孢噻肟和丙咪肟可以被认为是经验性治疗新生儿败血症的首选药物，因为这些药物具有最高的敏感性。

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