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首页> 外文期刊>Microbes and Environments >Complete Genome Sequencing and Comparative Genomic Analysis of the Thermotolerant Acetic Acid Bacterium, Acetobacter pasteurianus SKU1108, Provide a New Insight into Thermotolerance
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Complete Genome Sequencing and Comparative Genomic Analysis of the Thermotolerant Acetic Acid Bacterium, Acetobacter pasteurianus SKU1108, Provide a New Insight into Thermotolerance

机译：耐乙酸细菌巴斯德醋杆菌SKU1108的完整基因组测序和比较基因组分析，为耐热性提供了新的见解

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Acetobacter pasteurianus SKU1108 is a typical thermotolerant acetic acid bacterium. In this study, the complete genome sequence of the SKU1108 strain was elucidated, and information on genomic modifications due to the thermal adaptation of SKU1108 was updated. In order to obtain a clearer understanding of the genetic background responsible for thermotolerance, the SKU1108 genome was compared with those of two closely related complete genome strains, thermotolerant A. pasteurianus 386B and mesophilic A. pasteurianus NBRC 3283. All 24 “thermotolerant genes” required for growth at higher temperatures in the thermotolerant Acetobacter tropicalis SKU1100 strain were conserved in all three strains. However, these thermotolerant genes accumulated amino acid mutations. Some biased mutations, particularly those that occurred in xanthine dehydrogenase XdhA, may be related to thermotolerance. By aligning whole genome sequences, we identified ten SKU1108 strain-specific regions, three of which were conserved in the genomes of the two thermotolerant A. pasteurianus strains. One of the regions contained a unique paralog of the thermotolerant gene xdhA , which may also be responsible for conferring thermotolerance. Thus, comparative genomics of complete genome sequences may provide novel insights into the phenotypes of these thermotolerant strains.
机译：巴氏醋杆菌SKU1108是一种典型的耐热乙酸细菌。在这项研究中，阐明了SKU1108菌株的完整基因组序列，并更新了由于SKU1108的热适应而导致的基因组修饰信息。为了更清楚地了解引起耐热性的遗传背景，将SKU1108基因组与两个紧密相关的完整基因组菌株，即耐热巴氏巴斯德氏菌386B和嗜温巴氏巴斯德氏菌NBRC 3283进行了比较。需要所有24个“耐热基因”耐热的热带醋杆菌中的SKU1100菌株在较高温度下的生长在所有三个菌株中均保守。但是，这些耐热基因积累了氨基酸突变。一些有偏见的突变，特别是黄嘌呤脱氢酶XdhA中发生的那些，可能与耐热性有关。通过比对整个基因组序列，我们确定了十个SKU1108菌株特异性区域，其中三个在两个耐热巴斯德曲霉菌株的基因组中保守。区域之一包含耐热基因xdhA的独特旁系同源物，其也可能负责赋予耐热性。因此，完整基因组序列的比较基因组学可以为这些耐热菌株的表型提供新颖的见解。

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