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首页> 外文期刊>Nepal Journal of Epidemiology >Appropriateness of Antibiotic Use in Enteric fever inpatients in Tertiary Care Hospitals in Western Nepal: A Cross-Sectional Study
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Appropriateness of Antibiotic Use in Enteric fever inpatients in Tertiary Care Hospitals in Western Nepal: A Cross-Sectional Study

机译：尼泊尔西部三级保健医院肠道发热患者使用抗生素的适当性：一项跨部门研究

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Background: Enteric fever, also known as typhoid fever, is a commonly diagnosed disease in Nepal. Globally, enteric fever affects 21.6 million people and causes 216500 deaths annually. Appropriate use of antibiotics is a key element in the successful treatment of enteric fever. Objective: The study was aimed to study antibiotic use and their appropriateness in the patient with Enteric Fever. Methods: A cross-sectional study was carried out in two tertiary-care hospitals viz. Manipal Teaching Hospital (MTH) and Western Regional Hospital (WRH) in western Nepal between Aug- September 2010. Appropriateness in this study was assessed using Medication Appropriateness Index (MAI) criteria which include indication, effectiveness, dosage, correct directions, practical directions, drug-drug interactions, drug-disease interactions, duplication, duration and expense. Results: Mean use of antibiotics in WRH (2.18±0.87) was not significantly different (P = 0.015) from MTH (2.13±1.11). The Cephalosporin group of antibiotics was used widely to treat enteric fever in both hospitals. On average 1.12 Cephalosporin per patient in MTH and 0.93 Cephalosporin per patient in WRH were used. On average, we found that 31.7% in MTH and 39.5% in WRH of patient’s treatments with antibiotics were inappropriate. Other common types of inappropriateness are expensive drugs [90% (MTH), 92% (WRH)] duplication of antibiotics [53% (MTH), 822% (WRH)], prescribing high generation antibiotics [80% (MTH), 89% (WRH)], and practical direction [17% (MTH), 33% (WRH)]. Conclusion: Conclusively, more than thirty percent of patients in both of hospitals treated for enteric fever received inappropriate antibiotics. Hence we recommend future education or managerial intervention to improve appropriateness. DOI: http://dx.doi.org/10.3126je.v3i1.8289 Nepal Journal of Epidemiology 2013;3 (1): 236-242
机译：背景：肠热，也称为伤寒，是尼泊尔的一种常见疾病。在全球范围内，肠热每年影响2160万人，并导致216500人死亡。正确使用抗生素是成功治疗肠热的关键因素。目的：该研究旨在研究肠热患者的抗生素使用及其适用性。方法：在两家三级医院进行了横断面研究。尼泊尔西部的Manipal教学医院（MTH）和Western Western Hospital（WRH）在2010年8月至9月之间。本研究的适当性是根据药物适应性指数（MAI）的标准进行评估的，包括适应症，疗效，剂量，正确的方向，实际操作方向，药物相互作用，药物疾病相互作用，重复，持续时间和费用。结果：WRH（2.18±0.87）中的平均抗生素使用与MTH（2.13±1.11）没有显着差异（P = 0.015）。两家医院均广泛使用头孢菌素类抗生素治疗肠热。平均每名MTH患者使用1.12头孢菌素，在WRH中每患者平均使用0.93头孢菌素。平均而言，我们发现患者用抗生素治疗的MTH和WRH分别为31.7％和39.5％。其他不当行为的常见类型包括昂贵的药物[90％（MTH），92％（WRH）]，重复的抗生素[53％（MTH），822％（WRH）]，处方高世代抗生素[80％（MTH），89] ％（WRH）]和实用说明[17％（MTH），33％（WRH）]。结论：最终，两家医院接受肠热的患者中有30％以上接受了不合适的抗生素。因此，我们建议将来进行教育或管理干预以提高适当性。 DOI：http://dx.doi.org/10.3126je.v3i1.8289尼泊尔流行病学杂志2013; 3（1）：236-242

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