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首页> 外文期刊>Nepal Journal of Epidemiology >Reporting Adverse Drug Reactions Among Hospitalized Medical Patients: A Prospective Study From Tertiary Care Hospital in Western Nepal
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Reporting Adverse Drug Reactions Among Hospitalized Medical Patients: A Prospective Study From Tertiary Care Hospital in Western Nepal

机译：报告住院医疗患者中的药物不良反应：来自尼泊尔西部三级医院的前瞻性研究

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Background The risk of adverse drug reaction ranges nearly from zero to high level depending upon the drug itself and the patient factor. The process of detection, assessment, monitoring and reporting of adverse drug reaction is necessary to prevent its occurrence in future. Materials and Methods Information related to suspected Adverse Drug Reactions(ADRs) were collected by pharmacists from general medical ward using ADRs reporting form from Manipal Teaching Hospital (MTH)during ward rounds. The details of suspected drug, drug reaction and all related data were documented. Naranjo Algorithm, modified Hartwig and Siegel and modified Shumock and Thornton scale were used for assessment of causality, severity and preventability respectively. All suspected ADRs were reported to National Pharmacovigilance Center and then to Uppsala Monitoring centre through the electronic online data base named Vigiflow. Results Among 1,105 patients, 51 patients experienced ADR (4.61%). Incidents of ADRs were higher with antibiotics (47.06%) and Ceftriaxone was at top of list (15.69 %). Dermatological system (25.49%) and gastrointestinal system (19.61%) were affected more. About 33.33% of suspected drugs were discontinued. About 41.18% of ADRs required medical treatment where antihistaminic (24.32%) and antipruritic (21.62%) were most commonly used to treat ADRs. To sum up, 64.71% of ADRs were probable, 62.75% were mild in nature and 60.78% were probably preventable. Conclusion Finding of the study suggests that ADRs still pose serious health threat among hospitalized patients and as a matter of fact over 60% of them are preventable. Reporting of ADR scan provide effective measures to prevent the occurrence in the future in which the role of pharmacist is vital.DOI: http://dx.doi.org/10.3126je.v4i1.10135 Nepal Journal of Epidemiology 2014;4 (1): 330-336
机译：背景技术药物不良反应的风险取决于药物本身和患者因素，几乎从零到高水平不等。药物不良反应的检测，评估，监测和报告过程对于防止将来发生是必要的。资料和方法在病房查房期间，由药剂师从普通医疗病房使用来自Manipal教学医院（MTH）的ADR报告表收集与可疑药物不良反应（ADR）有关的信息。记录可疑药物的详细信息，药物反应和所有相关数据。 Naranjo算法，改进的Hartwig和Siegel以及改进的Shumock和Thornton量表分别用于评估因果关系，严重性和可预防性。所有可疑的ADR均通过名为Vigiflow的在线电子数据库报告给国家药物警戒中心，然后报告给乌普萨拉监测中心。结果在1,105例患者中，有51例发生ADR（4.61％）。抗生素的不良反应发生率更高（47.06％），头孢曲松钠居首位（15.69％）。皮肤系统（25.49％）和胃肠系统（19.61％）受影响更大。约有33.33％的可疑药物停产。约41.18％的ADR需要药物治疗，其中抗组胺药（24.32％）和止痒药（21.62％）最常用于治疗ADR。综上所述，ADR的可能性为64.71％，温和的为62.75％，可预防的为60.78％。结论研究发现表明，ADR在住院患者中仍然构成严重的健康威胁，事实上，其中60％以上是可以预防的。报告ADR扫描提供了有效的措施，以防止在将来发生药剂师至关重要的事件.DOI：http://dx.doi.org/10.3126je.v4i1.10135 Nepal of Epidemiology 2014; 4（ 1）：330-336

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