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首页> 外文期刊>Kaohsiung Journal of Medical Sciences >Association of MMP-2 and MMP-9 expression with recurrences in primary spontaneous pneumothorax
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Association of MMP-2 and MMP-9 expression with recurrences in primary spontaneous pneumothorax

机译：MMP-2和MMP-9表达与原发性自发性气胸复发的关系

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Primary spontaneous pneumothorax (PSP) is a common benign problem. However, PSP recurrence is still a troublesome complication for most patients. This study intended to determine the role of matrix metalloproteinase-2 (MMP-2) and MMP-9 in type II pneumocytes of patients with PSP and its relation with recurrence. Ninety-one patients who had undergone needlescopic video-assisted thoracoscopic surgery wedge resection of lung with identifiable blebs for PSP were included in this study. Immunohistochemical (IHC) staining was used to measure the expression of MMP-2 and MMP-9 in lung tissues of PSP patients. The results were further correlated with clinicopathological parameters and recurrence rates using chi-square or Fisher's exact test. The value of MMP-2 and MMP-9 for overall recurrence was analyzed by univariate and multivariable Cox regression model. IHC data revealed that MMP-2 and MMP-9 staining was predominantly observed in type II pneumocytes of patients with PSP. We found that MMP-2 and MMP-9 expression in PSP, especially male PSP patients, was significantly correlated with recurrence. In the univariate and multivariate analyses, MMP-2 and MMP-9 were statistically significant risk factors for overall recurrence in PSP patients. Therefore, high expression levels of MMP-2 and MMP-9 in type II pneumocytes show a positive correlation with PSP recurrence risk. Further studies are needed to validate whether reduction of MMP-2 and MMP-9 expression may be a promising way for decreasing the risk of PSP recurrence in the future.
机译：原发性自发性气胸（PSP）是一个常见的良性问题。但是，对于大多数患者来说，PSP复发仍然是一个麻烦的并发症。本研究旨在确定基质金属蛋白酶2（MMP-2）和MMP-9在PSP患者II型肺细胞中的作用及其与复发的关系。本研究纳入了91例接受了针刺电视辅助胸腔镜手术的肺楔形切除术并伴有PSP可辨认泡的患者。免疫组织化学（IHC）染色用于检测PSP患者肺组织中MMP-2和MMP-9的表达。使用卡方检验或Fisher精确检验将结果进一步与临床病理参数和复发率相关。通过单变量和多变量Cox回归模型分析了MMP-2和MMP-9对总体复发的价值。 IHC数据显示，在PSP患者的II型肺细胞中主要观察到MMP-2和MMP-9染色。我们发现PSP，尤其是男性PSP患者中的MMP-2和MMP-9表达与复发密切相关。在单因素和多因素分析中，MMP-2和MMP-9是PSP患者总体复发的统计学显着危险因素。因此，II型肺细胞中高表达的MMP-2和MMP-9与PSP复发风险呈正相关。需要进一步的研究来验证减少MMP-2和MMP-9表达是否可能是降低PSP复发风险的有希望的方法。

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