Acute renal failure and severe neurotoxicity after unintentional overdose of valacyclovir in a geriatric population: A case report

Marta Ferreira; Cristina Vega; Bego?a Rivas; Rafael Selgas

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Acute renal failure and severe neurotoxicity after unintentional overdose of valacyclovir in a geriatric population: A case report

机译：老年患者意外服用过量伐昔洛韦后的急性肾衰竭和严重的神经毒性：一例报告

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Valacyclovir, a prodrug of acyclovir with greater oral bioavailability, has been widely used in recent years for the treatment of herpes virus infections. After its hepatic metabolism, it is eliminated through glomerular filtration and active tubular secretion.1 Advanced age and renal failure increase the likelihood of side effects, such as neurotoxicity.2, 3 If toxicity is suspected, it is essential and early diagnosis and discontinuation of the medication. In selected cases, hemodialysis could accelerate the clearance of the drug and recovery from the toxic effects of the drug.4.

机译：伐昔洛韦是阿昔洛韦的前药，具有较高的口服生物利用度，近年来已广泛用于治疗疱疹病毒感染。肝脏代谢后，可通过肾小球滤过和活跃的肾小管分泌物消除。1高龄和肾功能衰竭会增加发生副作用的可能性，例如神经毒性。2，3如果怀疑毒性，则必须早期诊断和中止药物。在某些情况下，血液透析可以加速药物的清除并从药物的毒性作用中恢复。4。

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《Nefrologia》 |2018年第3期|共3页
作者
Marta Ferreira; Cristina Vega; Bego?a Rivas; Rafael Selgas;
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中图分类泌尿科学（泌尿生殖系疾病）;
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1. Acute valacyclovir overdose causing renal failure and neurotoxicity [J] . Rafstedt Karin, Hojer Jonas, Olsson Eva K., Clinical toxicology: the official journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists . 2017,第5期

机译：急性伐韦洛韦过量导致肾功能衰竭和神经毒性
2. Acute renal failure and severe neurotoxicity following valacyclovir. [J] . Carlon R, Possamai C, Corbanese U Intensive care medicine . 2005,第11期

机译：伐昔洛韦引起的急性肾功能衰竭和严重的神经毒性。
3. Acute Aluminum Neurotoxicity Secondary To Treatment Of Severe Hyperphosphatemia Of Acute Renal Failure And The K/DOQI Guidelines: A Case Report And Review Of The Literature [J] . Ogo I. Egbuna, Anirban Bose The Internet Journal of Nephrology . 2004,第2期

机译：重度高磷酸盐血症急性肾衰竭的继发急性铝神经毒性和K / DOQI指南：病例报告和文献复习
4. Therapeutic approach to severe acute renal failure [C] . Larry D.Cowgill Conference of the North American Veterinary . 1998

机译：治疗方法严重急性肾功能衰竭
5. Epidemiology of severe acute renal failure and prognosis for renal recovery in critically ill patients. [D] . Bagshaw, Sean Michael. 2005

机译：严重急性肾衰竭的流行病学和危重患者的肾脏恢复预后。
6. Case Report: Lithium overdose and delayed severe neurotoxicity: timing for renal replacement therapy and restarting of lithium [O] . Angharad N de Cates, Julien Morlet, Ayman Antoun Reyad, 1929

机译：病例报告：锂过量和延迟严重神经毒性：肾脏替代治疗的时机和锂的重新开始
7. A Case Report of Acute Renal Failure Caused by the Overdose of Vancomycin. Could Renal Blood Flow Analysis predict the Renal Failure? [O] . Yuichirou Tsuji, Hideo Yoshida, Makoto Inoue, 1997

机译：万古霉素过量造成急性肾功能衰竭的病例报告。肾血流分析可以预测肾功能衰竭吗？
8. The Initiation Phase of Experimental Acute Renal Failure: An Evaluation of Uranyl Nitrate-Induced Acute Renal Failure in the Rat. [R] . Flamenbaum, W., Hamburger, R. J., Huddleston, M. L., 1976

机译：实验性急性肾功能衰竭的起始阶段：评价硝酸铀酰诱导的大鼠急性肾功能衰竭。

Acute renal failure and severe neurotoxicity after unintentional overdose of valacyclovir in a geriatric population: A case report

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