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首页> 外文期刊>Neural regeneration research >Time-effect relationship of acupuncture on histopathology, ultrastructure, and neuroethology in the acute phase of cerebral hemorrhage
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Time-effect relationship of acupuncture on histopathology, ultrastructure, and neuroethology in the acute phase of cerebral hemorrhage

机译：针刺对脑出血急性期组织病理学，超微结构和神经行为学的时效关系

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Many clinical studies have addressed the treatment of acute cerebral hemorrhage using acupuncture. However, few studies have examined the relationship between time of acupuncture and curative effect on cerebral hemorrhage. By observing the effect of acupuncture on changes in histopathology, ultrastructure, and neuroethology in a cerebral hemorrhage model of rats, we have directly examined the time-effect relationship of acupuncture. The rat model of cerebral hemorrhage was produced by slowly injecting autologous blood to the right caudate nucleus. The experimental groups were: 3-, 9-, 24-, and 48-hour model groups; and 3-, 9-, 24-, and 48-hour acupuncture groups. The sham-operation group was used for comparison. Acupuncture was performed at the Neiguan (PC6) and Renzhong (DU26) acupoints, twice a day, 6 hours apart, for 5 consecutive days. Brain tissue changes were observed by light microscopy and transmission electron microscopy. Neuroethology was assessed using Bederson and Longa scores. Our results show that compared with the sham-operation and model groups, Bederson and Longa scores were lower in each acupuncture group, with visibly improved histopathology and brain tissue ultrastructure. Further, the results were better in the 3- and 9-hour acupuncture groups than the 24- and 48-hour acupuncture groups. Our findings show that acupuncture treatment can relieve pathological and ultrastructural deterioration and neurological impairment caused by the acute phase of cerebral hemorrhage, and may protect brain tissue during this period. In addition, earlier acupuncture intervention following cerebral hemorrhage (by 3 or 9 hours) is associated with a better treatment outcome.
机译：许多临床研究已经解决了使用针灸治疗急性脑出血的方法。但是，很少有研究检查针灸时间与脑出血的疗效之间的关系。通过观察针刺对大鼠脑出血模型组织病理学，超微结构和神经行为学变化的影响，我们直接检查了针刺的时效关系。通过将自体血液缓慢注入右尾状核来产生大鼠脑出血模型。实验组是：3、9、24和48小时模型组; 3、9、24和48小时针灸组。假手术组用于比较。内关（PC6）和仁中（DU26）穴位每天两次，相隔6小时，连续5天进行针刺。通过光学显微镜和透射电子显微镜观察脑组织变化。使用Bederson和Longa评分评估神经行为学。我们的结果表明，与假手术和模型组相比，每个针灸组的Bederson和Longa评分均较低，并且组织病理学和脑组织超微结构明显改善。此外，3小时和9小时针灸组的结果要好于24小时和48小时针灸组。我们的发现表明，针灸治疗可以缓解由脑出血急性期引起的病理和超微结构恶化以及神经功能障碍，并可以在此期间保护脑组织。此外，在脑出血后（3或9小时）进行早期针灸干预可带来更好的治疗效果。

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