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首页> 外文期刊>Neural regeneration research >Phrenic and intercostal nerves with rhythmic discharge can promote early nerve regeneration after brachial plexus repair in rats
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Phrenic and intercostal nerves with rhythmic discharge can promote early nerve regeneration after brachial plexus repair in rats

机译：伴有节律性放电的神经和肋间神经可促进大鼠臂丛神经修复后的早期神经再生

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Exogenous discharge can positively promote nerve repair. We, therefore, hypothesized that endogenous discharges may have similar effects. The phrenic nerve and intercostal nerve, controlled by the respiratory center, can emit regular nerve impulses; therefore these endogenous automatically discharging nerves might promote nerve regeneration. Action potential discharge patterns were examined in the diaphragm, external intercostal and latissimus dorsi muscles of rats. The phrenic and intercostal nerves showed rhythmic clusters of discharge, which were consistent with breathing frequency. From the first to the third intercostal nerves, spontaneous discharge amplitude was gradually increased. There was no obvious rhythmic discharge in the thoracodorsal nerve. Four animal groups were performed in rats as the musculocutaneous nerve cut and repaired was bland control. The other three groups were followed by a side-to-side anastomosis with the phrenic nerve, intercostal nerve and thoracodorsal nerve. Compound muscle action potentials in the biceps muscle innervated by the musculocutaneous nerve were recorded with electrodes. The tetanic forces of ipsilateral and contralateral biceps muscles were detected by a force displacement transducer. Wet muscle weight recovery rate was measured and pathological changes were observed using hematoxylin-eosin staining. The number of nerve fibers was observed using toluidine blue staining and changes in nerve ultrastructure were observed using transmission electron microscopy. The compound muscle action potential amplitude was significantly higher at 1 month after surgery in phrenic and intercostal nerve groups compared with the thoracodorsal nerve and blank control groups. The recovery rate of tetanic tension and wet weight of the right biceps were significantly lower at 2 months after surgery in the phrenic nerve, intercostal nerve, and thoracodorsal nerve groups compared with the negative control group. The number of myelinated axons distal to the coaptation site of the musculocutaneous nerve at 1 month after surgery was significantly higher in phrenic and intercostal nerve groups than in thoracodorsal nerve and negative control groups. These results indicate that endogenous autonomic discharge from phrenic and intercostal nerves can promote nerve regeneration in early stages after brachial plexus injury.
机译：外源放电可以积极促进神经修复。因此，我们假设内生放电可能具有类似的作用。受呼吸中枢控制的神经和肋间神经可发出规则的神经冲动;因此，这些内源性自动放电神经可能促进神经再生。在大鼠的diaphragm肌，肋间外和背阔肌中检查动作电位放电模式。 and神经和肋间神经表现出节律性放电，与呼吸频率一致。从第一至第三肋间神经，自发放电幅度逐渐增加。胸背神经无明显的节律性放电。在大鼠中进行了四个动物组的肌肉皮神经的切割和修复，并进行了温和的控制。其他三组接着进行with神经，肋间神经和胸背神经的并排吻合。用电极记录肌皮神经支配的二头肌肌肉的复合肌肉动作电位。用力位移传感器检测同侧和对侧二头肌的强直力。使用苏木精-伊红染色测量湿肌重量恢复率并观察病理变化。使用甲苯胺蓝染色观察神经纤维的数量，并使用透射电子显微镜观察神经超微结构的变化。 surgery和肋间神经组术后1个月的复合肌肉动作电位幅度明显高于胸背神经组和空白对照组。与阴性对照组相比，surgery神经，肋间神经和胸背神经组在术后2个月，右二头肌的强直张力和湿重的恢复率显着降低。 surgery神经和肋间神经组术后1个月，距肌皮神经接合部位远端的髓鞘轴突的数量显着高于胸背神经和阴性对照组。这些结果表明from神经和肋间神经的内源性自主神经放电可以促进臂丛神经损伤后早期的神经再生。

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