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首页> 外文期刊>Neurology International >Clinical risk factors predictive of thrombotic stroke with large cerebral infarction
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Clinical risk factors predictive of thrombotic stroke with large cerebral infarction

机译：临床危险因素可预测大面积脑梗死的血栓性中风

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Large cerebral infarctions have high morbidity and mortality. Patients with large cerebral infarctions may have recurrent ischemia as high as 8.1% within 7 days; highest among other types of strokes. Data regarding risk factors for large cerebral infarction in Asian populations are still scant. All adult (age ≥15 years old) patients with the diagnosis of thrombotic ischemic stroke who were treated at Srinagarind Hospital, Khon Kaen University, Thailand from January 2012 to December 2013 were studied. Large cerebral infarctions are defined by clinical criteria of having cerebral cortical impairment, brain stem or cerebellar dysfunction with infarction sizes of more than 1.5 cm. The association of various stroke risk factors and large infarction strokes were calculated using multiple logistic regression analysis. There were 276 thrombotic stroke patients who met the study criteria; classified as large cerebral infarctions in 59 patients (21.38%) and small cerebral infarctions in 217 patients (78.62%). Baseline characteristics and risk factors for stroke were comparable between both groups. The large cerebral infarction group had a significantly larger proportions of right internal carotid artery stenosis, plaques on the left side, left internal carotid artery stenosis, and internal carotid artery stenosis at any side than the small cerebral infarction group. Among various stroke risk factors, only internal carotid artery stenosis at any side was the only significant factor associated with large cerebral infarction with an adjusted odds ratio of 11.14 (95% CI: 3.46, 35.82). In conclusion, significant internal carotid artery stenosis is associated with large cerebral infarction.
机译：大型脑梗塞的发病率和死亡率很高。脑梗塞大的患者可能在7天内复发缺血率高达8.1％;在其他类型的中风中最高。关于亚洲人群大面积脑梗塞危险因素的数据仍然很少。研究对象是2012年1月至2013年12月在泰国孔敬大学Srinagarind医院接受治疗的所有诊断为血栓性缺血性中风的成人（≥15岁）患者。大型脑梗死的临床标准为脑皮质损伤，脑干或小脑功能障碍，梗死面积超过1.5厘米。使用多元逻辑回归分析计算各种卒中危险因素与大面积梗死卒中的关联。符合研究标准的276名血栓性中风患者;分为59例（21.38％）为大脑梗塞，217例（78.62％）为小脑梗塞。两组中风的基线特征和危险因素相当。与小脑梗死组相比，大脑梗死组的右颈内动脉狭窄，左侧斑块，左颈内动脉狭窄和任一侧颈内动脉狭窄的比例要大得多。在各种中风危险因素中，只有一侧的颈内动脉狭窄是与大脑梗死相关的唯一显着因素，调整后的优势比为11.14（95％CI：3.46，35.82）。总之，严重的颈内动脉狭窄与大面积脑梗死有关。

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