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首页> 外文期刊>National Journal of Maxillofacial Surgery >A randomized comparative prospective study of platelet-rich plasma, platelet-rich fibrin, and hydroxyapatite as a graft material for mandibular third molar extraction socket healing
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A randomized comparative prospective study of platelet-rich plasma, platelet-rich fibrin, and hydroxyapatite as a graft material for mandibular third molar extraction socket healing

机译：富含血小板的血浆，富含血小板的纤维蛋白和羟基磷灰石作为下颌第三磨牙拔牙窝愈合的移植材料的随机比较前瞻性研究

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Aim: The purpose of this study was to compare the efficacy of platelet-rich plasma (PRP), platelet-rich fibrin (PRF), and hydroxyapatite (HA) for reduction of pain and swelling, absence of dry socket, soft tissue healing, and bone regeneration after mandibular third molar extraction in human patients. Materials and Methods: Forty patients requiring extraction of mandibular third molars were randomly grouped as control, PRP, PRF, and HA-treated. The patients were assessed for postoperative pain, swelling, dry socket, and soft tissue healing on the 3rd, 7th, and 14th day of postoperative periods depending on the standard methods. Radiological assessment of the extraction site was done at 1, 2, and 6 months interval to compare the change in bone density in the sockets in control and treated patients. Results: Pain and swelling were less on PRP and PRF site when compared to HA and control site. PRP and PRF site showed better soft tissue healing when compared to HA and control site. Radiographic assessment showed comparatively lesser bone density values in PRP, PRF, and control site at 1, 2, and 6 months than HA site. Conclusion: Our study showed that PRP and PRF are better graft materials than HA regarding pain, swelling, dry socket, and soft tissue healing. Bone regeneration is induced promptly by HA as compared to other graft materials. However, a more elaborate study with a larger number of clinical cases is very much essential to be more conclusive regarding the efficacy of the graft materials.
机译：目的：本研究的目的是比较富含血小板的血浆（PRP），富含血小板的纤维蛋白（PRF）和羟基磷灰石（HA）在减轻疼痛和肿胀，无干窝，软组织愈合，人类患者下颌第三磨牙摘除后的骨骼和骨骼再生。材料和方法：将需要拔除下颌第三磨牙的40例患者随机分为对照组，PRP，PRF和HA治疗组。在第3天，第7天和第14天对患者进行术后疼痛，肿胀，窝干和软组织愈合的评估手术时间的长短取决于标准方法。在1、2和6个月的间隔内对提取部位进行放射学评估，以比较对照组和治疗组患者窝中骨密度的变化。结果：与HA和对照部位相比，PRP和PRF部位的疼痛和肿胀较少。与HA和对照部位相比，PRP和PRF部位表现出更好的软组织愈合。影像学评估显示，在1、2和6个月时，PRP，PRF和对照部位的骨密度值均比HA部位小。结论：我们的研究表明，就疼痛，肿胀，干窝和软组织愈合而言，PRP和PRF是比HA更好的移植材料。与其他移植材料相比，HA可迅速诱导骨再生。然而，对移植物材料的有效性进行更确切的研究对于更大量的临床病例进行更详尽的研究非常重要。

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