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首页> 外文期刊>NeuroImage: Clinical >Brain connectivity and postural control in young traumatic brain injury patients: A diffusion MRI based network analysis
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Brain connectivity and postural control in young traumatic brain injury patients: A diffusion MRI based network analysis

机译：年轻的颅脑外伤患者的大脑连接性和姿势控制：基于扩散核磁共振成像的网络分析

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Our previous research on traumatic brain injury (TBI) patients has shown a strong relationship between specific white matter (WM) diffusion properties and motor deficits. The potential impact of TBI-related changes in network organization of the associated WM structural network on motor performance, however, remains largely unknown. Here, we used diffusion tensor imaging (DTI) based fiber tractography to reconstruct the human brain WM networks of 12 TBI and 17 control participants, followed by a graph theoretical analysis. A force platform was used to measure changes in body posture under conditions of compromised proprioceptive and/or visual feedback. Findings revealed that compared with controls, TBI patients showed higher betweenness centrality and normalized path length, and lower values of local efficiency, implying altered network organization. These results were not merely a consequence of differences in number of connections. In particular, TBI patients displayed reduced structural connectivity in frontal, parieto-premotor, visual, subcortical, and temporal areas. In addition, the decreased connectivity degree was significantly associated with poorer balance performance. We conclude that analyzing the structural brain networks with a graph theoretical approach provides new insights into motor control deficits following brain injury. Highlights ? We examine the brain connectome in relation to traumatic brain injury (TBI). ? Altered structural connectivity is found in the networks of TBI patients. ? Poor balance performance is associated with decreases in structural connectivity. ? Structural connectivity analysis adds new information to standard DTI analyses.
机译：我们先前对创伤性脑损伤（TBI）患者的研究表明，特定白质（WM）扩散特性与运动障碍之间存在密切的关系。然而，与WBI结构网络相关的网络组织的TBI相关变化对电机性能的潜在影响仍然未知。在这里，我们使用基于扩散张量成像（DTI）的纤维束描记术重建了12个TBI和17个对照参与者的人脑WM网络，然后进行了图论分析。使用力平台来测量在本体感受和/或视觉反馈受损的情况下身体姿势的变化。研究结果表明，与对照组相比，TBI患者显示出更高的中间集中度和标准化的路径长度，以及更低的局部效率值，这意味着网络组织发生了变化。这些结果不仅仅是连接数量不同的结果。特别是，TBI患者在额叶，顶前运动，视觉，皮层下和颞叶区域的结构连接性降低。此外，连接度降低与平衡性能较差显着相关。我们得出的结论是，使用图论方法分析结构性脑网络可提供对脑损伤后运动控制缺陷的新见解。强调 ？我们检查与创伤性脑损伤（TBI）相关的大脑连接体。 ？在TBI患者的网络中发现结构连接性发生了变化。 ？平衡性能差与结构连接性下降有关。 ？结构连通性分析为标准DTI分析增加了新信息。

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