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首页> 外文期刊>NeuroImage: Clinical >Reduced cortical thickness with increased lifetime burden of PTSD in OEF/OIF Veterans and the impact of comorbid TBI
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Reduced cortical thickness with increased lifetime burden of PTSD in OEF/OIF Veterans and the impact of comorbid TBI

机译：降低皮质厚度，增加OEF / OIF退伍军人PTSD的一生负担，以及合并TBI的影响

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Posttraumatic stress disorder (PTSD) and mild traumatic brain injury (mTBI) in military personnel is increasing dramatically following the OEF/OIF conflicts and is associated with alterations to brain structure. The present study examined the relationship between PTSD and cortical thickness, and its possible modification by mTBI, in a 104-subject OEF/OIF veteran cohort ranging in age from 20 to 62years. For each participant, two T1-weighted scans were averaged to create high-resolution images for calculation of regional cortical thickness. PTSD symptoms were assessed using the Clinician Administered PTSD Scale (CAPS) and scores were derived based on the previous month's symptoms (“current”) and a Cumulative Lifetime Burden of PTSD (CLB-P) reflecting the integral of CAPS scores across the lifetime. Mild TBI was diagnosed using the Boston Assessment of TBI-Lifetime (BAT-L). Results demonstrated a clear negative relationship between current PTSD severity and thickness in both postcentral gyri and middle temporal gyri. This relationship was stronger and more extensive when considering lifetime burden (CLB-P), demonstrating the importance of looking at trauma in the context of an individual's lifetime, rather than only at their current symptoms. Finally, interactions with current PTSD only and comorbid current PTSD and mTBI were found in several regions, implying an additive effect of lifetime PTSD and mTBI on cortical thickness.
机译：在OEF / OIF冲突之后，军事人员的创伤后应激障碍（PTSD）和轻度颅脑损伤（mTBI）急剧增加，并且与脑结构的改变有关。本研究在年龄为20至62岁的104名OEF / OIF退伍军人队列中研究了PTSD与皮质厚度之间的关系，以及其可能通过mTBI进行的修饰。对于每个参与者，将两次T1加权扫描取平均值，以创建用于计算区域皮层厚度的高分辨率图像。使用临床医生管理的PTSD量表（CAPS）评估PTSD症状，并根据前一个月的症状（“当前”）和PTSD的累积终生负担（CLB-P）得出得分，反映了终生CAPS得分的积分。轻度TBI是根据波士顿TBI终身评估（BAT-L）诊断的。结果表明，在中央后回和颞中回当前的PTSD严重程度和厚度之间存在明显的负相关。在考虑终生负担（CLB-P）时，这种关系更加牢固和广泛，这表明在个人一生的背景下而不是仅根据他们目前的症状来研究创伤的重要性。最后，在几个区域发现了仅与当前PTSD以及共存的当前PTSD和mTBI的相互作用，这暗示了寿命PTSD和mTBI对皮层厚度的累加效应。

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