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首页> 外文期刊>Neuroscience Journal >Subchronic Oral Bromocriptine Methanesulfonate Enhances Open Field Novelty-Induced Behavior and Spatial Memory in Male Swiss Albino Mice
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Subchronic Oral Bromocriptine Methanesulfonate Enhances Open Field Novelty-Induced Behavior and Spatial Memory in Male Swiss Albino Mice

机译：亚慢性口服溴隐亭甲烷磺酸盐增强雄性瑞士白化病小鼠的旷野新奇诱导的行为和空间记忆。

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This study set out to assess the neurobehavioral effects of subchronic, oral bromocriptine methanesulfonate using the open field and the Y-maze in healthy male mice. Sixty adult Swiss albino mice were assigned into three groups. Controls received normal saline, while test groups received bromocriptine methanesulfonate at 2.5 and 5 mg/kg/day, respectively, for a period of 21 days. Neurobehavioral tests were carried out on days 1 and 21 after administration. Open field assessment on day 1 after administration revealed significant increase in grooming at 2.5 and 5 mg/kg, while horizontal and vertical locomotion showed no significant changes. Day 1 also showed no significant changes in Y-maze alternation. On day 21, horizontal locomotion, rearing, and grooming were increased significantly at 2.5 and 5 mg/kg doses after administration; also, spatial memory was significantly enhanced at 2.5 mg/kg. In conclusion, the study demonstrates the ability of oral bromocriptine to affect neurobehavior in normal mice. It also suggests that there is a cumulative effect of oral bromocriptine on the behaviors studied with more changes being seen after subchronic administration rather than after a single oral dose.
机译：这项研究着手在健康雄性小鼠中使用开放视野和Y迷宫评估次慢性口服溴隐亭甲磺酸盐的神经行为作用。将六十只成年瑞士白化病小鼠分为三组。对照组接受生理盐水，而测试组分别接受2.5和5μmg/ kg /天的溴隐亭甲磺酸盐，持续21天。给药后第1天和第21天进行神经行为测试。用药后第1天进行的野外评估表明，修饰水平分别为2.5和5μmg/ kg，而水平和垂直运动均无明显变化。第1天也没有显示Y-迷宫交替的显着变化。在第21天，给药后水平运动，饲养和修饰在2.5和5μmg/ kg剂量时显着增加。同样，空间记忆在2.5μmg/ kg时显着增强。总之，该研究证明了口服溴隐亭影响正常小鼠神经行为的能力。这也表明口服溴隐亭对所研究的行为具有累积作用，在亚慢性给药后而不是在单次口服给药后，观察到更多变化。

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