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首页> 外文期刊>Neuroscience Journal >Evaluation of Motor Neuron Excitability by CMAP Scanning with Electric Modulated Current
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Evaluation of Motor Neuron Excitability by CMAP Scanning with Electric Modulated Current

机译：通过CMAP扫描电调制电流评估运动神经元兴奋性

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Introduction. Compound Muscle Action Potential (CMAP) scan is a noninvasive promissory technique for neurodegenerative pathologies diagnosis. In this work new CMAP scan protocols were implemented to study the influence of electrical pulse waveform on peripheral nerve excitability.Methods. A total of 13 healthy subjects were tested. Stimulation was performed with an increasing intensities range from 4 to 30 mA. The procedure was repeated 4 times per subject, using a different single pulse stimulation waveform: monophasic square and triangular and quadratic and biphasic square.Results. Different waveforms elicit different intensity-response amplitude curves. The square pulse needs less current to generate the same response amplitude regarding the other waves and this effect is gradually decreasing for the triangular, quadratic, and biphasic pulse, respectively.Conclusion. The stimulation waveform has a direct influence on the stimulus-response slope and consequently on the motoneurons excitability. This can be a new prognostic parameter for neurodegenerative disorders.
机译：介绍。复合肌肉动作电位（CMAP）扫描是一种用于神经退行性病变诊断的无创性技术。在这项工作中，采用了新的CMAP扫描协议来研究电脉冲波形对周围神经兴奋性的影响。总共测试了13名健康受试者。刺激的强度范围从4到30µmA。每个受试者使用不同的单脉冲刺激波形重复该过程4次：单相正方形和三角形以及二次和双相正方形。不同的波形会引起不同的强度响应幅度曲线。方波需要较少的电流来产生相对于其他波相同的响应幅度，并且这种影响分别对于三角形，二次和双相脉冲逐渐减小。刺激波形直接影响刺激响应斜率，进而影响运动神经元的兴奋性。这可能是神经退行性疾病的新的预后参数。

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