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首页> 外文期刊>National Journal of Maxillofacial Surgery >Correlation of CD133 and Oct-4 expression with clinicopathological and demographic parameters in oral squamous cell carcinoma patients
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Correlation of CD133 and Oct-4 expression with clinicopathological and demographic parameters in oral squamous cell carcinoma patients

机译：口腔鳞状细胞癌患者CD133和Oct-4表达与临床病理和人口统计学参数的相关性

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摘要

Objective: Squamous cell carcinoma of oral cavity is one of the most common cancers of Indian subcontinent with the 5-year survival rate of 50% despite the recent advances in the treatment. The aim of the present study was to study cancer stem cell markers CD133 and Oct-4 in oral squamous cell carcinoma (OSCC) patients and their correlation with clinicopathological variables. Materials and Methods: This was a prospective study which included 50 cases of histopathologically proven squamous cell carcinoma of oral cavity. Expression of CD133 and Oct-4 was evaluated by immunohistochemistry (IHC) and their expression was correlated with various clinicopathological and demographic parameters. Results: CD133 expression was seen in 20.6% cases of clinical Stage I–II and in 79.4% of clinical stage of III-IV OSCC patients, the difference being statistically significant with the P = 0.048. There was no statistically significant association between CD133 expression and any other clinicopathological or demographic variable. Oct-4 was expressed only in one case. Conclusions: CD133 expression was significantly seen higher in Stage III–IV tumors, the stem cells may be responsible for the aggressiveness of the OSCCs and these stem cells can be potential prognostic markers and targets for the future targeted therapy.
机译：目的：尽管最近取得了进展，但口腔鳞状细胞癌是印度次大陆最常见的癌症之一，其5年生存率达到50％。本研究的目的是研究口腔鳞状细胞癌（OSCC）患者的癌症干细胞标记CD133和Oct-4及其与临床病理变量的相关性。材料和方法：这是一项前瞻性研究，包括50例经病理组织学证实的口腔鳞状细胞癌。通过免疫组织化学（IHC）评价CD133和Oct-4的表达，并将它们的表达与各种临床病理和人口统计学参数相关联。结果：CD133表达见于临床I–II期的20.6％病例和III-IV OSCC患者的79.4％的临床阶段，差异具有统计学意义，P = 0.048。 CD133表达与任何其他临床病理或人口统计学变量之间无统计学意义的关联。仅在一种情况下表达了Oct-4。结论：在III–IV期肿瘤中CD133的表达明显较高，干细胞可能是OSCC侵袭性的原因，这些干细胞可以作为潜在的预后标志物和未来靶向治疗的靶标。

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