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首页> 外文期刊>NeuroImage: Clinical >Single-subject-based whole-brain MEG slow-wave imaging approach for detecting abnormality in patients with mild traumatic brain injury
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Single-subject-based whole-brain MEG slow-wave imaging approach for detecting abnormality in patients with mild traumatic brain injury

机译：基于单对象的全脑MEG慢波成像方法可检测轻度脑外伤患者的异常情况

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Traumatic brain injury (TBI) is a leading cause of sustained impairment in military and civilian populations. However, mild TBI (mTBI) can be difficult to detect using conventional MRI or CT. Injured brain tissues in mTBI patients generate abnormal slow-waves (1–4Hz) that can be measured and localized by resting-state magnetoencephalography (MEG). In this study, we develop a voxel-based whole-brain MEG slow-wave imaging approach for detecting abnormality in patients with mTBI on a single-subject basis. A normative database of resting-state MEG source magnitude images (1–4Hz) from 79 healthy control subjects was established for all brain voxels. The high-resolution MEG source magnitude images were obtained by our recent Fast-VESTAL method. In 84 mTBI patients with persistent post-concussive symptoms (36 from blasts, and 48 from non-blast causes), our method detected abnormalities at the positive detection rates of 84.5%, 86.1%, and 83.3% for the combined (blast-induced plus with non-blast causes), blast, and non-blast mTBI groups, respectively. We found that prefrontal, posterior parietal, inferior temporal, hippocampus, and cerebella areas were particularly vulnerable to head trauma. The result also showed that MEG slow-wave generation in prefrontal areas positively correlated with personality change, trouble concentrating, affective lability, and depression symptoms. Discussion is provided regarding the neuronal mechanisms of MEG slow-wave generation due to deafferentation caused by axonal injury and/or blockages/limitations of cholinergic transmission in TBI. This study provides an effective way for using MEG slow-wave source imaging to localize affected areas and supports MEG as a tool for assisting the diagnosis of mTBI. Highlights ? A voxel-based whole-brain MEG slow-wave source imaging method for mild TBI. ? The new approach showed 84.5% positive detection rate in 84 mild TBI patients. ? The new approach detected loci of injury in mild TBI patients on a single-subject basis. ? MEG slow-wave source imaging revealed brain areas vulnerable to mild TBI. ? MEG slow-wave generations correlated with mild TBI symptoms.
机译：颅脑外伤（TBI）是军事和平民人口持续受损的主要原因。但是，轻度TBI（mTBI）可能难以使用常规MRI或CT进行检测。 mTBI患者的受伤的脑组织会产生异常的慢波（1-4Hz），可以通过静止状态的脑磁图（MEG）对其进行测量和定位。在这项研究中，我们开发了一种基于体素的全脑MEG慢波成像方法，可以在单个受试者的基础上检测mTBI患者的异常情况。建立了针对所有脑体素的来自79位健康对照受试者的静止状态MEG源幅值图像（1-4Hz）的规范数据库。高分辨率的MEG源幅值图像是通过我们最近的Fast-VESTAL方法获得的。在84例持续性脑震荡后症状的mTBI患者中（爆炸引起的为36例，非爆炸引起的为48例），我们的方法对异常（爆炸引起的）的阳性检出率为84.5％，86.1％和83.3％。加上非爆炸原因），爆炸和非爆炸mTBI组。我们发现前额叶，顶叶后叶，颞下叶，海马和小脑区域特别容易遭受头部创伤。结果还表明，前额叶区域的MEG慢波产生与人格改变，注意力不集中，情感不稳定和抑郁症状呈正相关。讨论了由于TBI中轴突损伤和/或胆碱能传递受阻/限制引起的脱除咖啡因而引起的MEG慢波产生的神经元机制。这项研究为使用MEG慢波源成像定位患处提供了有效的方法，并支持MEG作为辅助诊断mTBI的工具。强调 ？基于体素的全脑MEG慢波源成像方法用于轻度TBI。 ？新方法在84例轻度TBI患者中显示出84.5％的阳性检出率。 ？新方法可在单受试者基础上检测轻度TBI患者的损伤位点。 ？ MEG慢波源成像显示易受轻度TBI影响的大脑区域。 ？ MEG慢波产生与轻度TBI症状相关。

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