...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Nigerian Journal of Physiological Sciences >Genistein Precipitated Hypothyroidism, Altered Leptin and C-Reactive Protein Synthesis in Pregnant Rats
【24h】

Genistein Precipitated Hypothyroidism, Altered Leptin and C-Reactive Protein Synthesis in Pregnant Rats

机译：Genistein促甲状腺功能减退症，瘦素和C反应蛋白合成在怀孕的大鼠中。

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Summary: Genistein is an isoflavone constituent of soya. This study examined the mechanism by which genistein produced adverse effects in pregnant laboratory rats. Pregnant rats were divided into control (Con) and genistein (Gen) force fed (2 mg/kg) groups. At terminal gestation day (GD) ranging from 0-20, the rats were sacrificed, and blood samples and amniotic fluids were collected. Thyroid hormone, C-reactive protein (CRP) and leptin assay was carried using the blood samples. Leptin was also assayed in the placenta and amniotic fluid supernatant. Oral exposure of pregnant rats to genistein significantly altered maternal T3, (GD18; Con 1.65 ± 0.01, Gen 1.03 ± 0.04 nmol/L), T4 (GD6; Con 29.60 ± 0.00, Gen 36.04 ± 1.29 nmol/L), Leptin (Placenta GD20; Con 0.08 ± 0.01, Gen 0.31 ± 0.02 ng/ml, amniotic fluid ;GD 20; Con 0.02 ± 0.00, Gen 0.35 ± 0.05 ng/ml) in genistein group. These changes were accompanied with loss of embryonic implants and a decrease in fetal and placental weights. The CRP level was significantly decreased and increased at the onset and toward late pregnancy respectively. Oral exposure of pregnant rats to genistein precipitated hypothyroidism, altered some metabolic hormones with a reduction in fetal and placental growth and increased resorption of embryonic implants. Keywords: Genistein, embryonic implants, pregnancy, thyroid hormone, leptin, C - reactive protein.
机译：简介：金雀异黄素是大豆的异黄酮成分。这项研究检查了染料木黄酮对怀孕的实验大鼠产生不良影响的机制。将妊娠大鼠分为对照组（Con）和金雀异黄素（Gen）强饲（2mg / kg）组。在0至20的妊娠末日（GD），处死大鼠，并收集血液样品和羊水。使用血样进行甲状腺激素，C反应蛋白（CRP）和瘦素测定。在胎盘和羊水上清液中还测定了瘦蛋白。孕鼠口服染料木黄酮显着改变母体T3（GD18; Con 1.65±0.01，Gen 1.03±0.04 nmol / L），T4（GD6; Con 29.60±0.00，Gen 36.04±1.29 nmol / L），瘦素（胎盘）染料木黄酮组GD20; Con 0.08±0.01，Gen 0.31±0.02 ng / ml，羊水; GD 20; Con 0.02±0.00，Gen 0.35±0.05 ng / ml）。这些变化伴随着胚胎植入物的丢失以及胎儿和胎盘重量的减少。 CRP水平在怀孕初期和妊娠后期分别显着降低和升高。孕鼠口服染料木黄酮会导致甲状腺功能减退，改变某些代谢激素，从而降低胎儿和胎盘的生长，并增加胚胎植入物的吸收。关键词：染料木黄酮胚胎植入妊娠甲状腺激素瘦素C反应蛋白

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号