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Magnetic resonance imaging–guided laser interstitial thermal therapy for previously treated hypothalamic hamartomas

机译：磁共振成像引导下激光间质热疗法治疗先前治疗的下丘脑错构瘤

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OBJECTIVE Hypothalamic hamartomas (HHs) are associated with gelastic seizures and the development of medically refractory epilepsy. Magnetic resonance imaging–guided laser interstitial thermal therapy (MRg-LITT) is a minimally invasive ablative treatment that may have applicability for these deep-seated lesions. Here, the authors describe 3 patients with refractory HHs who they treated with MRg-LITT. METHODS An institutional review board–approved prospective database of patients undergoing Visualase MRg-LITT was retrospectively reviewed. Demographic and historical medical data, including seizure and medication histories, previous surgeries, procedural details, and surgical complications, along with radiological interpretation of the HHs, were recorded. The primary outcome was seizure freedom, and secondary outcomes included medication reduction, seizure frequency, operative morbidity, and clinical outcome at the latest follow-up. RESULTS All 3 patients in the multi-institutional database had developed gel...
机译：目的下丘脑错构瘤（HHs）与全能性癫痫发作和难治性癫痫的发展有关。磁共振成像引导的激光间隙热疗（MRg-LITT）是一种微创消融治疗，可能适用于这些深部病变。在这里，作者描述了3名接受MRg-LITT治疗的难治性HH患者。方法回顾性审查机构审查委员会批准的接受Visualase MRg-LITT的患者的前瞻性数据库。记录了人口统计和历史医学数据，包括癫痫发作和用药史，以前的手术，手术细节和手术并发症，以及对HH的放射学解释。主要结局是癫痫发作的自由性，次要结局包括减少药物使用，癫痫发作的频率，手术发病率和最新随访的临床结局。结果多机构数据库中的所有3例患者均出现了凝胶...

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