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首页> 外文期刊>Nucleus >A role for Rtt109 in buffering gene-dosage imbalance during DNA replication
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A role for Rtt109 in buffering gene-dosage imbalance during DNA replication

机译：Rtt109在缓冲DNA复制过程中基因剂量失衡中的作用

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摘要

Chromatin can function as an integrator of DNA-related processes, allowing communication, for example, between DNA replication and gene transcription. Such communication is needed to overcome the gene-dosage imbalance introduced during DNA replication, when certain genes are replicated prior to others. Increased transcription of early replicating genes could alter regulatory balances. This does not occur, suggesting a mechanism that suppresses expression from newly replicated DNA. Critical to this buffering is Rtt109, which acetylates the internal K56 residue of newly synthesized histone H3 prior to incorporation onto DNA. H3K56ac distinguishes replicated from non-replicated DNA, communicating this information to the transcription machinery to ensure expression homeostasis during S phase.
机译：染色质可以充当DNA相关过程的整合者，从而允许在DNA复制和基因转录之间进行交流。当某些基因先于其他基因被复制时，需要这种交流来克服在DNA复制期间引入的基因剂量失衡。早期复制基因转录的增加可能会改变调节平衡。不会发生这种情况，表明存在一种抑制新复制的DNA表达的机制。 Rtt109对这种缓冲至关重要，它可以在掺入DNA之前乙酰化新合成的组蛋白H3的内部K56残基。 H3K56ac可以区分复制的DNA和未复制的DNA，并将此信息传达给转录机制，以确保S期表达稳态。

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