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首页> 外文期刊>Nucleus >The Rtt107 BRCT scaffold and its partner modification enzymes collaborate to promote replication
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The Rtt107 BRCT scaffold and its partner modification enzymes collaborate to promote replication

机译：Rtt107 BRCT支架及其伴侣修饰酶共同促进复制

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Faithful duplication of the entire genome during each cell cycle is key for genome maintenance. Each stage of DNA replication, including initiation, progression, and termination, is tightly regulated. Some of these regulations enable replisomes to overcome tens of thousands of template obstacles that block DNA synthesis. Previous studies have identified a large number of proteins that are dedicated to this mission, including protein modification enzymes and scaffold proteins. Protein modification enzymes can bestow fast and reversible changes on many substrates, and thus are ideal for coordinating multiple events needed to promptly overcome replication impediments. Scaffold proteins can support specific protein-protein interactions that enable protein complex formation, protein recruitment, and partner enzyme functions. Taken together with previous studies, our recent work elucidates that a group of modification and scaffold proteins form several complexes to aid replication progression and are particularly important for synthesizing large replicons. Additionally, our work reveals that the intrinsic plasticity of the replication initiation program can be used to compensate for deficient replication progression.~(1) Hang LE, Peng J, Tan W, Szakal B, Menolfi D, Sheng Z, Lobachev K, Branzei D, Feng W, Zhao X. Rtt107 is a multi-functional scaffold supporting replication progression with partner SUMO and ubiquitin ligases. Mol Cell 2015; 60:268-79; PMID:26439300; http://dx.doi.org/10.1016/j.molcel.2015.08.023[Crossref], [PubMed], [Web of Science ®]?[Google Scholar].
机译：在每个细胞周期中忠实复制整个基因组是维持基因组的关键。 DNA复制的每个阶段，包括起始，进行和终止，都受到严格的调控。其中一些法规使复制体能够克服成千上万个阻碍DNA合成的模板障碍。先前的研究已经确定了专门用于此任务的大量蛋白质，包括蛋白质修饰酶和支架蛋白质。蛋白质修饰酶可以在许多底物上赋予快速且可逆的变化，因此是协调迅速克服复制障碍所需的多个事件的理想选择。支架蛋白可以支持特定的蛋白-蛋白相互作用，从而实现蛋白复合物的形成，蛋白募集和伴侣酶功能。结合以前的研究，我们最近的工作阐明了一组修饰蛋白和支架蛋白形成了多种复合物以帮助复制进程，并且对于合成大型复制子特别重要。此外，我们的工作表明复制启动程序的内在可塑性可用于补偿复制不足的进展。〜（1）杭乐，彭J，谭W，Szakal B，Menolfi D，Sheng Z，Lobachev K，Branzei D，Feng W，ZhaoX。Rtt107是支持与伴侣SUMO和泛素连接酶一起复制进行的多功能支架。摩尔细胞2015; 60：268-79; PMID：26439300; http://dx.doi.org/10.1016/j.molcel.2015.08.023[Crossref]、[PubMed]、[Web of Science®]？[Google Scholar]。

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