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首页> 外文期刊>Notulae Botanicae Horti Agrobotanici Cluj-Napoca >Chemical Composition, Antioxidant, Anticancer Properties and Toxicity Evaluation of Leaf Essential Oil of Cupressus sempervirens
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Chemical Composition, Antioxidant, Anticancer Properties and Toxicity Evaluation of Leaf Essential Oil of Cupressus sempervirens

机译：柏柏叶精油的化学成分，抗氧化，抗癌性能及毒性评价

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The essential oil isolated by hydro-distillation from Cupressus sempervirens (Cypress) leaves was analysed by GC-MS and tested for antioxidant and in vitro as well as in vivo anticancer activities. In addition, the toxicity effect of the essential oil was studied using normal Swiss mice. Eighteen components of Cypress essential oil were identified and the main essential oil components were ?±-pinene (29.21%), ?′3-carene (18.92%), ?±-cedrol (12.25%), ?±-terpinolene (7.66%) and limonene (5.50%). Cupressus sempervirens essential oil was able to reduce the stable, purple-colored radical DPPH into yellow-colored DPPH reaching 50% of reduction with IC50 value = 290.09 ??g mL-1. The in vitro anticancer activity of the essential oil was studied against two human promyelocytic leukemia cell lines (HL-60 and NB4) and experimental animals model cancer cell line (EACC). Cypress essential oil exerted the highest cytotoxic activity with a LC50 of 333.79 ?μg mL-1 against NB4 followed by HL-60 and EACC cell lines (LC50 of 365.41, and 372.43 ?μg mL-1, respectively). Regarding in vivo anticancer study, pre-initiation treatment with the essential oil was more effective than initiation and post-initiation treatments respectively on the tumor (EACC) transplanted female mice (increase lifespan (%), decrease total EACC number and increase dead cells). In toxicity study, serum urea, transaminases and lactate dehydrogenase were increased. The results obtained from this study showed that the Cypress essential oil possesses antioxidant and anticancer properties, taking into consideration its mild toxicity.
机译：通过气相蒸馏从柏树（Cypressus empervirens）（柏树）叶片中水蒸馏分离出的精油通过GC-MS进行分析，并测试其抗氧化剂和体外以及体内的抗癌活性。另外，使用普通的瑞士小鼠研究了香精油的毒性作用。确定了18种赛普拉斯精油成分，主要精油成分为α--烯（29.21％），α'3-烯烃（18.92％），α±-香酚（12.25％），α±萜品烯（7.66％） ）和柠檬烯（5.50％）。柏柏木精油能够将稳定的紫色自由基DPPH还原为黄色DPPH，达到还原率的50％，IC50值为290.09 ?? g mL-1。研究了香精油对两种人早幼粒细胞白血病细胞系（HL-60和NB4）和实验动物模型癌细胞系（EACC）的体外抗癌活性。赛普拉斯精油具有最高的细胞毒性活性，对NB4的LC50为333.79μgmL-1，其次为HL-60和EACC细胞系（LC50分别为365.41和372.43μμgmL-1）。关于体内抗癌研究，精油的启动前治疗分别比移植肿瘤（EACC）的雌性小鼠启动和后启动治疗更有效（延长寿命（％），减少总EACC数量并增加死细胞） 。在毒性研究中，血清尿素，转氨酶和乳酸脱氢酶增加。从这项研究获得的结果表明，考虑到其轻度毒性，赛普拉斯精油具有抗氧化和抗癌特性。

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