• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Nucleus >Consequences of a tight squeeze: Nuclear envelope rupture and repair
【24h】

Consequences of a tight squeeze: Nuclear envelope rupture and repair

机译：紧紧挤压的后果：核被膜破裂和修复

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Cell migration through tight spaces can induce substantial deformations of the nucleus and cause nuclear envelope (NE) rupture, resulting in uncontrolled exchange of nuclear and cytosolic proteins. These events can cause DNA damage and, in severe cases, nuclear fragmentation, challenging the integrity of the genomic material. Cells overcome NE ruptures during interphase by repairing the NE using components of the endosomal sorting complexes required for transport (ESCRT) machinery. Paralleling the molecular mechanism used during NE reformation in late mitosis, ESCRT-III subunits and the associated AAA-ATPase VPS4B are recruited to NE rupture sites and help restore NE integrity. While these findings are common to many cell types, they are particularly relevant in the context of cancer metastasis, where nuclear deformation and rupture could drive genomic instability in invading cells and further promote cancer progression. At the same time, inhibiting NE repair may offer new therapeutic approaches to specifically target invasive cancer cells.
机译：通过狭窄空间的细胞迁移会引起细胞核大量变形，并导致核被膜（NE）破裂，从而导致不受控制的核蛋白和胞质蛋白交换。这些事件可能会导致DNA损伤，在严重的情况下还会导致核分裂，从而挑战基因组材料的完整性。细胞通过使用运输（ESCRT）机械所需的内体分选复合物的成分修复NE，从而克服了中间相期间的NE破裂。平行于晚期有丝分裂的NE重整过程中使用的分子机制，ESCRT-III亚基和相关的AAA-ATPase VPS4B被募集到NE破裂部位，并有助于恢复NE的完整性。尽管这些发现对于许多细胞类型来说是共同的，但在癌症转移的背景下它们尤其相关，在这种情况下，核变形和破裂可能会导致入侵细胞的基因组不稳定，并进一步促进癌症的发展。同时，抑制NE修复可能会提供新的治疗方法，专门针对侵袭性癌细胞。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号