Super-resolution binding activated localization microscopy through reversible change of DNA conformation

Aleksander Szczurek; Udo Birk; Hans Knecht; Jurek Dobrucki; Sabine Mai; Christoph Cremer

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Super-resolution binding activated localization microscopy through reversible change of DNA conformation

机译：通过可逆的DNA构象变化超高分辨率结合激活的定位显微镜

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Methods of super-resolving light microscopy (SRM) have found an exponentially growing range of applications in cell biology, including nuclear structure analyses. Recent developments have proven that Single Molecule Localization Microscopy (SMLM), a type of SRM, is particularly useful for enhanced spatial analysis of the cell nucleus due to its highest resolving capability combined with very specific fluorescent labeling. In this commentary we offer a brief review of the latest methodological development in the field of SMLM of chromatin designated DNA Structure Fluctuation Assisted Binding Activated Localization Microscopy (abbreviated as fBALM) as well as its potential future applications in biology and medicine.

机译：超分辨光学显微镜（SRM）的方法已经发现，在细胞生物学（包括核结构分析）中的应用范围呈指数增长。最近的发展证明，单分子定位显微镜（SMLM）是一种SRM，由于其最高的分辨能力和非常特异的荧光标记，对于增强细胞核的空间分析特别有用。在这篇评论中，我们简要介绍了染色质命名为DNA结构波动辅助结合激活定位显微镜（简称为fBALM）的SMLM领域的最新方法学发展及其在生物学和医学领域的潜在未来应用。

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《Nucleus》 |2018年第1期|共8页
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Aleksander Szczurek; Udo Birk; Hans Knecht; Jurek Dobrucki; Sabine Mai; Christoph Cremer;
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中图分类细胞生物学;
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1. Super-resolution morphological dissemination of intercalating dye in single DNA molecules via binding activated localization microscopy [J] . Guenyoung Park, Suresh Kumar Chakkarapani, Soyeong Ju, 中国化学快报（英文版） . 2018,第003期

机译：通过结合激活的定位显微镜在单个DNA分子中超高分辨率形态学嵌入染料的分布
2. Acoustic wave sparsely activated localization microscopy (AWSALM): Super-resolution ultrasound imaging using acoustic activation and deactivation of nanodroplets [J] . Zhang Ge, Harput Sevan, Lin Shengtao, Applied Physics Letters . 2018,第1期

机译：声波稀疏激活定位显微镜（AWSALM）：使用声波激活和纳米液滴失活的超高分辨率超声成像
3. Imaging chromatin nanostructure with binding-activated localization microscopy based on DNA structure fluctuations [J] . Nucleic Acids Research . 2017,第8期

机译：基于DNA结构波动的成像染色质纳米结构具有结合活化定位显微镜
4. Hydrogen/Deuterium Exchange Mass Spectrometry Reveals Quaternary Conformational Changes for AMP Activated Protein Kinase upon Binding of Small Molecules [C] . Rachelle R. Landgraf, Michael J. Chalmers, Bruce D. Pascal, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2011

机译：氢/氘交换质谱仪显示在小分子结合时AMP活化蛋白激酶的季度构象变化
5. An allosterically regulated reversible mechanical molecular switch: A de novo protein maquette functions as a redox/ionic strength sensor coupling chemical binding energy or charge interactions to conformational change. [D] . Grosset, Anne Marie. 2000

机译：变构调控的可逆机械分子开关：从头蛋白模型起氧化还原/离子强度传感器的作用，将化学结合能或电荷相互作用耦合到构象变化。
6. Super-resolution binding activated localization microscopy through reversible change of DNA conformation [O] . Aleksander Szczurek, Udo Birk, Hans Knecht, 2018

机译：通过可逆的DNA构象变化超高分辨率结合激活的定位显微镜
7. Imaging chromatin nanostructure with binding-activated localization microscopy based on DNA structure fluctuations [O] . Aleksander Szczurek, Ludger Klewes, Jun Xing, 2017

机译：基于DNA结构波动的成像染色质纳米结构具有结合活化定位显微镜

Super-resolution binding activated localization microscopy through reversible change of DNA conformation

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