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Clinical and nutritional factors associated with dialysis initiation and mortality in chronic kidney disease

机译：与慢性肾脏病透析开始和死亡相关的临床和营养因素

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BackgroundChronic kidney disease is worldwide recognized as a public health problem due to high rates of morbidity and mortality. At the end stage of the disease, which the glomerular filtration rate is equal or less than 15?ml/min/1.73?m2, dialysis initiation is usually indicated. In the absence of a consensus on the best time of beginning, the aim of this study was to identify clinical and nutritional factors associated with clinical outcomes with the start of dialysis and death. MethodsIn a prospective cohort of 82 patients, clinical (underlying renal disease, renal survival time, systolic and diastolic blood pressure, estimated glomerular filtration rate) and nutritional data (protein intake, anthropometry, bioelectrical impedance test, and strength handgrip) were collected. We used mean and standard deviation or median and association of the variables with the outcome entry into dialysis or death, and a Cox regression model was applied. Statistical significance was p ResultsFifty-eight patients were included in group 1—G1 (without dialysis)—and 24 patients in group 2—G2 (dialysis). The groups were different in blood urea nitrogen ( p = p =?0.003), estimated glomerular filtration rate ( p =?0.002), and serum phosphorus ( p =?0.002). After multivariate analysis, only serum albumin (HR 0.342, p =?0.004) and glomerular filtration rate (HR 0.001, p =?0.001) were associated with entry into dialysis and death. ConclusionsWe concluded that lower levels of serum albumin and glomerular filtration rate values are associated with entry into dialysis or death.
机译：背景技术由于高发病率和高死亡率，慢性肾脏病已被公认为公共卫生问题。在疾病的末期，肾小球滤过率等于或小于15？ml / min / 1.73？m 2 ，通常提示开始透析。在最佳开始时间尚无共识的情况下，本研究的目的是确定与透析和死亡开始有关的临床结局相关的临床和营养因素。方法收集了82位患者的前瞻性队列研究，包括临床（基础肾脏疾病，肾脏存活时间，收缩压和舒张压，估计的肾小球滤过率）和营养数据（蛋白质摄入，人体测量学，生物电阻抗测试和强度手握）。我们使用变量的均值和标准差或变量的中位数和关联与进入透析或死亡的结局，并应用Cox回归模型。统计学意义为p结果。第1组-G1组（无透析）包括58例患者，第2组-G2组有24例患者（透析）。各组的血液尿素氮（p = p = 0.003），肾小球滤过率估计值（p = 0.002）和血清磷（p = 0.002）不同。经过多变量分析后，只有血清白蛋白（HR 0.342，p =？0.004）和肾小球滤过率（HR 0.001，p =？0.001）与透析和死亡有关。结论我们得出结论，较低水平的血清白蛋白和肾小球滤过率值与进入透析或死亡有关。

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