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首页> 外文期刊>Therapeutic apheresis and dialysis: official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy >Timing of Dialysis Initiation and Mortality Risk in Chronic Kidney Disease: A Meta‐Analysis
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Timing of Dialysis Initiation and Mortality Risk in Chronic Kidney Disease: A Meta‐Analysis

机译：透析引发和慢性肾病中死亡率风险的定时：META分析

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Abstract The optimal time of dialysis initiation among patients with chronic kidney disease (CKD) is unclear in recent years. We performed a meta‐analysis to assess the association of early vs. late initiation of dialysis with estimated glomerular filtration rate. PUBMED, EMBASE, the Cochrane Library, and article reference lists were searched for relevant observational trials. A pooled hazard ratio (HR) with 95% CI was used to estimate the mortality risk. Twenty‐six cohort studies and one randomized controlled trial were identified. Early start of dialysis was associated with the increased risk of mortality (HR?=?1.23, 95% CI: 1.04–1.43) compared with late start of dialysis. In the subgroup analysis, age younger than 65?years at the early start of dialysis demonstrated higher mortality (HR?=?1.20, 95% CI: 1.05–1.35) than the late start. Compared with peritoneal dialysis, the pooled HR with HD was 1.25 (95% CI: 1.17–1.34). Early start of dialysis increased the mortality risk compared with late start among patients with CKD.
机译：摘要近年来尚不清楚慢性肾疾病患者透析透析发育的最佳时间。我们进行了荟萃分析，以评估与估计的肾小球过滤速率的透析早期开始的早期比率。搜索有关观察试验的PUBMED，EMBASE，COCHRANE图书馆和文章参考文章。使用95％CI的汇集危险比（HR）用于估计死亡率风险。确定了二十六项队列研究和一个随机对照试验。与晚期开始的透析开始，透析的早期开始与增加的死亡风险增加（HR？= 1.23,95％CI：1.04-1.43）。在亚组分分析中，年龄小于65岁以下的年初透析的年初呈现出较高的死亡率（HR？=？1.20,95％CI：1.05-1.35）比后开始。与腹膜透析相比，具有HD的合并的HR为1.25（95％CI：1.17-1.34）。与CKD患者的患者的晚期开始，透析早期开始增加了死亡率风险。

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