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Modulation of chromatin access during adipocyte differentiation

机译：脂肪细胞分化过程中染色质通路的调控

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Cellular development requires reprogramming of the genome to modulate the gene program of the undifferentiated cell and allow expression of the gene program unique to differentiated cells. A number of key transcription factors involved in this reprogramming of preadipocytes to adipocytes have been identified; however, it is not until recently that we have begun to understand how these factors act at a genome-wide scale. In a recent publication we have mapped the genome-wide changes in chromatin structure during differentiation of 3T3-L1 preadipocytes and shown that a major reorganization of the chromatin landscape occurs within few hours following the addition of the adipogenic cocktail. In addition, we have mapped the genome-wide profiles of several of the early adipogenic transcription factors and shown that they act in a highly cooperative manner to drive this dramatic remodeling process.
机译：细胞发育需要对基因组进行重编程以调节未分化细胞的基因程序，并允许表达分化细胞特有的基因程序。已经确定了许多将前脂肪细胞重编程为脂肪细胞的关键转录因子。然而，直到最近我们才开始了解这些因素如何在全基因组范围内起作用。在最近的出版物中，我们已绘制了3T3-L1前脂肪细胞分化过程中染色质结构的全基因组变化图，并表明在添加成脂混合物后数小时内，染色质景观发生了重大重组。此外，我们已经绘制了一些早期成脂转录因子的全基因组图谱，并表明它们以高度合作的方式起作用，以驱动这一戏剧性的重塑过程。

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