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Modulation of chromatin access during adipocyte differentiation

机译：脂肪细胞分化过程中染色质通路的调控

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Cellular development requires reprogramming of the genome to modulate the gene program of the undifferentiated cell and allow expression of the gene program unique to differentiated cells. A number of key transcription factors involved in this reprogramming of preadipocytes to adipocytes have been identified; however, it is not until recently that we have begun to understand how these factors act at a genome-wide scale. In a recent publication we have mapped the genome-wide changes in chromatin structure during differentiation of 3T3-L1 preadipocytes and shown that a major reorganization of the chromatin landscape occurs within few hours following the addition of the adipogenic cocktail. In addition, we have mapped the genomewide profiles of several of the early adipogenic transcription factors and shown that they act in a highly cooperative manner to drive this dramatic remodeling process.
机译：细胞发育需要对基因组进行重编程以调节未分化细胞的基因程序，并允许表达分化细胞特有的基因程序。已经确定了许多将前脂肪细胞重编程为脂肪细胞的关键转录因子。然而，直到最近我们才开始了解这些因素如何在全基因组范围内起作用。在最近的出版物中，我们已绘制了3T3-L1前脂肪细胞分化过程中染色质结构的全基因组变化图，并表明在添加成脂混合物后数小时内，染色质景观发生了重大重组。此外，我们已经绘制了一些早期成脂转录因子的全基因组图谱，并表明它们以高度合作的方式起作用，以驱动这一戏剧性的重塑过程。

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