首页> 外文期刊>Nuclear Medicine Review >Does quantification of myocardial perfusion SPECT study differ while image reconstruction is carried out using iteration algorithm instead of filtered back-projection? - preliminary report
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Does quantification of myocardial perfusion SPECT study differ while image reconstruction is carried out using iteration algorithm instead of filtered back-projection? - preliminary report

机译:使用迭代算法而不是滤波后的反投影进行图像重建时,心肌灌注SPECT研究的量化是否有所不同? - 初步报告

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BACKGROUND: The purpose of this study was to compare the performance of two reconstruction algorithms: conventional filtered back-projection (FBP) and an iterative algorithm -ITW- in quantitative analysis of myocardial perfusion SPECT studies. The defect size and defect severity were assessed on 99m Tc - MIBI images reconstructed using both methods and estimation of sensitivity in the detection of perfusion deficits and myocardial viability were performed as well. METHODS AND RESULTS: The study group comprised 43 patients (38 men and 5 women) in the age of 40-73 years (mean 59 years). Heart perfusion scintigraphy was performed following an injection of 22 to 25 mCi 99m Tc-MIBI for exercise and rest myocardial perfusion study. Images were reconstructed using FBP and ITW algorithms. Defect size (DS) was quantified by a threshold program and CEqual programme. Defect severity (nadir) was calculated as the ratio of minimal/maximum counts from bull?s eye polar map. Coronary arteriography was performed in all patients. RESULTS: Defect size calculated by threshold method on resting images did not differ between reconstruction methods (p=0.61 for cut-off 50% and p = 0.24 for cut-off 60%); defect severity was higher on images reconstructed with ITW (CI 0.95 = 2.4%?5.2% of maximal counts). CONCLUSIONS: Sensitivity for detection of heart perfusion defects and estimation of myocardial viability were similar on images reconstructed by both algorithms.
机译:背景:本研究的目的是比较两种重建算法的性能:常规滤波反投影(FBP)和迭代算法-ITW-在定量心肌灌注SPECT研究中的应用。在使用两种方法重建的99m Tc-MIBI图像上评估了缺损的大小和严重程度,并评估了在检测血流灌注不足和心肌活力方面的敏感性。方法和结果:研究组包括43例患者(38例男性和5例女性),年龄40-73岁(平均59岁)。在进行22至25 mCi 99m Tc-MIBI注射后,进行心脏灌注闪烁显像,以进行运动和静息心肌灌注研究。使用FBP和ITW算法重建图像。缺陷大小(DS)通过阈值程序和CEqual程序进行量化。缺陷严重程度(最低点)是根据牛眼极坐标图的最小/最大计数之比计算得出的。所有患者均行冠状动脉造影。结果:通过阈值法对静止图像计算的缺陷大小在两种重建方法之间没有差异(截止值为50%的p = 0.61,截止值为60%的p = 0.24)。使用ITW重建的图像的缺陷严重性更高(CI 0.95 =最大计数的2.4%?5.2%)。结论:两种算法重建的图像在检测心脏灌注缺陷和估计心肌活力方面的敏感性相似。

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