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首页> 外文期刊>Nutrition Research and Practice >Effect of paternal folate deficiency on placental folate content and folate receptor α expression in rats
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Effect of paternal folate deficiency on placental folate content and folate receptor α expression in rats

机译：父亲叶酸缺乏对大鼠胎盘叶酸含量和叶酸受体α表达的影响

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>We investigated the effect of paternal folate status on folate content and expression of the folate transporter folate receptor α (FRα) in rat placental tissues. Rats were mated after males were fed a diet containing 0 mg of folic acid/kg of diet (paternal folate-deficient, PD) or 8 mg folic acid/kg of diet (paternal folate-supplemented, PS) for 4 weeks. At 20 days of gestation, the litter size, placental weight, and fetal weight were measured, and placental folate content (n = 8/group) and expression of FRα (n = 10/group) were analyzed by microbiological assay and Western blot analysis, respectively. Although there was no difference observed in litter size or fetal weight, but significant reduction (10%) in the weight of the placenta was observed in the PD group compared to that in the PS group. In the PD group, placental folate content was significantly lower (by 35%), whereas FRα expression was higher (by 130%) compared to the PS group. Our results suggest that paternal folate status plays a critical role in regulating placental folate metabolism and transport.
机译：>我们研究了父本叶酸状态对大鼠胎盘组织中叶酸含量和叶酸转运蛋白叶酸受体α（FRα）表达的影响。在雄性饲喂含0 mg叶酸/ kg饮食（母体缺乏叶酸，PD）或8 mg叶酸/ kg饮食（补充母体叶酸，PS）的雄性大鼠后，进行交配。妊娠20天时，测量其产仔数，胎盘重量和胎儿重量，并通过微生物学分析和Western blot分析法分析胎盘中叶酸的含量（n = 8 /组）和FRα的表达（n = 10 /组）。 ， 分别。尽管在产仔数或胎儿体重上没有观察到差异，但是与PS组相比，PD组的胎盘重量显着降低（10％）。在PD组中，与PS组相比，胎盘中叶酸含量显着降低（降低了35％），而FRα表达则更高（降低了130％）。我们的结果表明，父亲叶酸的状态在调节胎盘叶酸的代谢和运输中起着至关重要的作用。

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