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首页> 外文期刊>Nutrition Research and Practice >Sasa borealis leaves extract improves insulin resistance by modulating inflammatory cytokine secretion in high fat diet-induced obese C57/BL6J mice
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Sasa borealis leaves extract improves insulin resistance by modulating inflammatory cytokine secretion in high fat diet-induced obese C57/BL6J mice

机译：芥末叶提取物通过调节高脂饮食诱导的肥胖C57 / BL6J小鼠中的炎性细胞因子分泌来改善胰岛素抵抗

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>Obesity is considered a mild inflammatory state, and the secretion of inflammation-related cytokines rises as adipose tissue expands. Inflammatory cytokines, including tumor necrosis factor-α (TNF-α), interlukin 6 (IL-6) and monocyte-chemoattractant protein 1 (MCP-1), are modulated by adipose tissue and known to play an important role in insulin resistance which is the common characteristics of obesity related disorders. In this study we analyzed the effects of Sasa borealis leaves extract on inflammatory cytokines and insulin resistance in diet induced obese C57/BL6J mice. The obese state was induced by a high fat diet for 20 weeks and then the mice were divided into two groups; obese control group (OBC, n = 7) and experimental group (OB-SBE, n = 7). The OBC group was fed a high fat diet and the OB-SBE group was fed a high fat diet containing 5% Sasa borealis leaves extract (SBE) for 12 weeks. We also used mice fed a standard diet as a normal control (NC, n = 7). The body weight and adipose tissue weight in the OB group were significantly higher than those in the NC group. The effects of the high fat diet were reduced by SBE treatments, and the body weight and adipose tissue deposition in the OB-SBE group were significantly decreased compared to the OBC group. The OBC group showed higher serum glucose and insulin levels which resulted in a significant increase of incremental area under the curve (IAUC) and HOMA-IR than the NC group. Also, serum leptin, TNF-α, and IL-6 levels were significantly higher in the OBC group than in the NC group. In contrast, the OB-SBE group showed a reversal in the metabolic defects, including a decrease in glucose, insulin, IAUC, HOMA-IR, TNF-α, IL-6 and leptin levels. These results suggest that BSE can suppress increased weight gain and/or fat deposition induced by a high fat diet and theses effects are accompanied by modulation of the inflammatory cytokines, TNF-α and IL-6 secretion resulting in improved insulin resistance.
机译：肥胖被认为是轻度的炎症状态，与炎症相关的细胞因子的分泌随着脂肪组织的扩张而增加。炎症细胞因子，包括肿瘤坏死因子-α（TNF-α），白介素6（IL-6）和单核细胞趋化蛋白1（MCP-1），受脂肪组织调节，并在胰岛素抵抗中起重要作用。是肥胖相关疾病的共同特征。在这项研究中，我们分析了五味子叶提取物对饮食诱导的肥胖C57 / BL6J小鼠中炎性细胞因子和胰岛素抵抗的影响。通过高脂饮食诱导肥胖状态20周，然后将小鼠分为两组。肥胖对照组（OBC，n = 7）和实验组（OB-SBE，n = 7）。给OBC组喂高脂饮食，给OB-SBE组喂高脂饮食，其中含有5％的北方芦笋叶提取物（SBE），持续12周。我们还使用喂食标准饮食的小鼠作为正常对照（NC，n = 7）。 OB组的体重和脂肪组织重量显着高于NC组。与OBC组相比，OBE-SBE组降低了高脂饮食的影响，并且OB-SBE组的体重和脂肪组织沉积显着降低。与NC组相比，OBC组显示出更高的血清葡萄糖和胰岛素水平，这导致曲线下增加面积（IAUC）和HOMA-IR显着增加。另外，OBC组的血清瘦素，TNF-α和IL-6水平显着高于NC组。相反，OB-SBE组显示出代谢缺陷的逆转，包括葡萄糖，胰岛素，IAUC，HOMA-IR，TNF-α，IL-6和瘦素水平的降低。这些结果表明，BSE可以抑制高脂饮食诱导的体重增加和/或脂肪沉积，并且这些作用伴随着炎症细胞因子，TNF-α和IL-6分泌的调节，从而改善了胰岛素抵抗。

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