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首页> 外文期刊>Leukemia Research and Treatment >Immunopathogenesis of Human T-Cell Leukemia Virus Type-1-Associated Myelopathy/Tropical Spastic Paraparesis: Recent Perspectives
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Immunopathogenesis of Human T-Cell Leukemia Virus Type-1-Associated Myelopathy/Tropical Spastic Paraparesis: Recent Perspectives

机译：人类T细胞白血病病毒1型相关的脊髓病/热带痉挛性轻瘫的免疫发病机制：最新观点。

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摘要

Human T-cell leukemia virus type-1 (HTLV-1) is a replication-competent human retrovirus associated with two distinct types of disease only in a minority of infected individuals: the malignancy known as adult T-cell leukemia (ATL) and a chronic inflammatory central nervous system disease HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). HAM/TSP is a chronic progressive myelopathy characterized by spastic paraparesis, sphincter dysfunction, and mild sensory disturbance in the lower extremities. Although the factors that cause these different manifestations of HTLV-1 infection are not fully understood, accumulating evidence from host population genetics, viral genetics, DNA expression microarrays, and assays of lymphocyte function suggests that complex virus-host interactions and the host immune response play an important role in the pathogenesis of HAM/TSP. Especially, the efficiency of an individual's cytotoxic T-cell (CTL) response to HTLV-1 limits the HTLV-1 proviral load and the risk of HAM/TSP. This paper focuses on the recent advances in HAM/TSP research with the aim to identify the precise mechanisms of disease, in order to develop effective treatment and prevention.
机译：人类T细胞白血病1型病毒（HTLV-1）是一种具有复制能力的人类逆转录病毒，仅在少数感染个体中与两种不同类型的疾病相关：称为成人T细胞白血病（ATL）的恶性肿瘤和慢性炎症性中枢神经系统疾病HTLV-1相关性脊髓病/热带痉挛性轻瘫（HAM / TSP）。 HAM / TSP是一种慢性进行性脊髓病，其特征为痉挛性轻瘫，括约肌功能障碍和下肢轻度感觉障碍。尽管导致HTLV-1感染这些不同表现形式的因素尚不完全清楚，但来自宿主群体遗传学，病毒遗传学，DNA表达微阵列和淋巴细胞功能测定的证据积累表明，复杂的病毒-宿主相互作用和宿主免疫反应起着重要作用。在HAM / TSP的发病机制中起着重要作用。特别是，个体对HTLV-1的细胞毒性T细胞（CTL）反应的效率限制了HTLV-1的前病毒载量和HAM / TSP的风险。本文着眼于HAM / TSP研究的最新进展，旨在发现疾病的确切机制，以便开发有效的治疗和预防方法。

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