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首页> 外文期刊>Nutrients >Pomegranate Peel Extract Prevents Bone Loss in a Preclinical Model of Osteoporosis and Stimulates Osteoblastic Differentiation in Vitro
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Pomegranate Peel Extract Prevents Bone Loss in a Preclinical Model of Osteoporosis and Stimulates Osteoblastic Differentiation in Vitro

机译：石榴皮提取物可预防骨质疏松症临床前模型中的骨质流失并刺激体外成骨细胞分化

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The nutritional benefits of pomegranate have attracted great scientific interest. The pomegranate, including the pomegranate peel, has been used worldwide for many years as a fruit with medicinal activity, mostly antioxidant properties. Among chronic diseases, osteoporosis, which is associated with bone remodelling impairment leading to progressive bone loss, could eventually benefit from antioxidant compounds because of the involvement of oxidative stress in the pathogenesis of osteopenia. In this study, with in vivo and ex vivo experiments, we investigated whether the consumption of pomegranate peel extract (PGPE) could limit the process of osteopenia. We demonstrated that in ovariectomized (OVX) C57BL/6J mice, PGPE consumption was able to significantly prevent the decrease in bone mineral density (?31.9%; p 0.001 vs. OVX mice) and bone microarchitecture impairment. Moreover, the exposure of RAW264.7 cells to serum harvested from mice that had been given a PGPE-enriched diet elicited reduced osteoclast differentiation and bone resorption, as shown by the inhibition of the major osteoclast markers. In addition, PGPE appeared to substantially stimulate osteoblastic MC3T3-E1 alkaline phosphatase (ALP) activity at day 7, mineralization at day 21 and the transcription level of osteogenic markers. PGPE may be effective in preventing the bone loss associated with ovariectomy in mice, and offers a promising alternative for the nutritional management of this disease.
机译：石榴的营养价值引起了极大的科学兴趣。石榴，包括石榴皮，已在世界范围内被用作具有药用活性（主要是抗氧化特性）的水果多年。在慢性疾病中，骨质疏松症与导致重度骨质流失的骨骼重塑受损有关，由于氧化应激与骨质减少症的发病机理有关，最终可以从抗氧化剂中受益。在这项研究中，通过体内和体外实验，我们研究了食用石榴皮提取物（PGPE）是否可以限制骨质减少的过程。我们证明，在去卵巢（OVX）C57BL / 6J小鼠中，食用PGPE能够显着防止骨矿物质密度的降低（？31.9％;与OVX小鼠相比，p <0.001）和骨微结构损伤。此外，将RAW264.7细胞暴露于从富含PGPE饮食的小鼠那里收获的血清中，会引起破骨细胞的分化和骨吸收的降低，这主要是由于抑制了破骨细胞标志物所显示的。此外，PGPE似乎在第7天基本上刺激了成骨细胞MC3T3-E1碱性磷酸酶（ALP）的活性，在第21天的矿化和成骨标记的转录水平。 PGPE可能有效预防小鼠卵巢切除术引起的骨丢失，并为该疾病的营养管理提供了有希望的替代方法。

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